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This paper is in the following e-collection/theme issue:

Cancer Prognosis Models and Machine Learning (140) Clinical Informatics (2306) Decision Support for Health Professionals (2268) Electronic Health Records (1749) Innovations and Technology for Cancer Prevention and Screening (268) Secondary Use of Clinical Data for Research and Surveillance (641) Machine Learning (3232) Children and Young People With Cancer, Pediatric Oncology (110) Colon and Rectal Cancer (82)

Published on in Vol 11 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/64506, first published .
Doctor shows colon health on tablet with medical icons

Predicting Early-Onset Colorectal Cancer in Individuals Below Screening Age Using Machine Learning and Real-World Data: Case Control Study

Predicting Early-Onset Colorectal Cancer in Individuals Below Screening Age Using Machine Learning and Real-World Data: Case Control Study

Authors of this article:

Chengkun Sun1 Author Orcid Image ;   Erin Mobley2, 3 Author Orcid Image ;   Michael Quillen4 Author Orcid Image ;   Max Parker4 Author Orcid Image ;   Meghan Daly3 Author Orcid Image ;   Rui Wang5 Author Orcid Image ;   Isabela Visintin3 Author Orcid Image ;   Ziad Awad3 Author Orcid Image ;   Jennifer Fishe6 Author Orcid Image ;   Alexander Parker2, 7 Author Orcid Image ;   Thomas George2, 4 Author Orcid Image ;   Jiang Bian8 Author Orcid Image ;   Jie Xu1 Author Orcid Image
Article Authors Cited by (9) Tweetations (1) Metrics

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  1. Le D, Pham T. Colorectal cancer worldwide: epidemiological trends, economic burden, and the promise of AI-driven solutions. Exploration of Medicine 2025;6 View
  2. Ni W, Zhang B, Gao Y, Jiang J, Ye Y, Chen J, Lin X, Yu H, Wang L, Xiao C. Explainable machine learning model for predicting early recurrence and distant metastasis after surgery in early-onset colorectal cancer. Surgery 2026;195:109973 View
  3. Ajjawi I, Kim I, Smani S, Palencia P, Diaz G, Lee W, Kim I, Sprenkle P, Leapman M. Machine learning approaches to optimize the integration of sociodemographic factors for predicting cancer-specific survival among patients with high-risk prostate cancer. Current Urology 2026 View
  4. bin Mohamad Salmi M, binti Zainal Abidin F, Nor A, Elagili F. High Diagnostic Yield of Colonoscopy in Symptomatic Adults Aged Under Fifty Years: Missed Opportunities for Early Detection of Colorectal Cancer in Southeast Asia. Turkish Journal of Colorectal Disease 2026;36(2):49 View
  5. Farkas D, Baracs J, Ritter Z, Sipos D. Multiparametric Radiomics for Characterization and Outcome Prediction in Colorectal Cancer: The Central Role of Diagnostic Imaging. Cancers 2026;18(16):2578 View
  6. Grześkiewicz-Szostak M, Gęca K, Skórzewska M. Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care. Current Oncology Reports 2026;28(1) View
  7. Murthy S, Schuh A. How advances in machine learning drive early detection and risk prediction of early-onset colorectal cancer. Frontiers in Oncology 2026;16 View
  8. Alegre-Martinez A, Cabañas-Alite L, Fernández-Benet I, Sánchez-Casalongue M, Martin-Moreno J. Understanding the Rising Incidence of Early-Onset Colorectal Cancer: Life-Course Determinants and Opportunities for Primary Prevention. Cancers 2026;18(17):2852 View

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  1. Rewatkar R, Bhagat Patil A, Umalkar R. Intelligent Strategies for ICT. View