Predicting Early-Onset Colorectal Cancer in Individuals Below Screening Age Using Machine Learning and Real-World Data: Case Control Study

Chengkun Sun   ¹ , MS ;   Erin Mobley   ^{2, 3} , PhD ;   Michael Quillen   ⁴ , MD ;   Max Parker   ⁴ , MD ;   Meghan Daly   ³ , MD ;   Rui Wang   ⁵ , PhD ;   Isabela Visintin   ³ , MD ;   Ziad Awad   ³ , MD ;   Jennifer Fishe   ⁶ , MD ;   Alexander Parker   ^{2, 7} , PhD ;   Thomas George   ^{2, 4} , MD ;   Jiang Bian   ⁸ , PhD ;   Jie Xu   ¹ , PhD

¹ Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, United States

² University of Florida Health Cancer Center, University of Florida, Gainesville, FL, United States

³ Department of Surgery, University of Florida, Jacksonville, FL, United States

⁴ Department of Medicine, University of Florida, Gainesville, FL, United States

⁵ Center for Data Solutions, University of Florida, Jacksonville, FL, United States

⁶ Department of Emergency Medicine, University of Florida, Jacksonville, FL, United States

⁷ College of Medicine, University of Florida, Jacksonville, FL, United States

⁸ Indiana University Indianapolis, Indianapolis, IN, United States