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Epithelioid Hemangioendothelioma as a Dangerous, Easy to Miss, and Nearly Impossible to Clinically Diagnose Condition: Case Report

Epithelioid Hemangioendothelioma as a Dangerous, Easy to Miss, and Nearly Impossible to Clinically Diagnose Condition: Case Report

Primary cutaneous EHE is rare and should prompt suspicion of metastatic disease, especially if multifocal in the skin [4]. Owing to their rarity and similarities to other diagnoses, cutaneous EHE lesions are commonly misdiagnosed [5]. Previous studies suggest the diagnosis of strictly cutaneous EHE incurs a 17% mortality rate at 3 years, highlighting its relatively aggressive nature [6].

Kayd Pulsipher, Samantha Mills, Blair Harris, Rene Bermudez, Muammar Arida, Jonathan Crane

JMIR Dermatol 2024;7:e52493

Deep Learning–Based Identification of Tissue of Origin for Carcinomas of Unknown Primary Using MicroRNA Expression: Algorithm Development and Validation

Deep Learning–Based Identification of Tissue of Origin for Carcinomas of Unknown Primary Using MicroRNA Expression: Algorithm Development and Validation

The TCGA data set contains samples from 18 different cancer types representing 9648 samples, of which 365 were metastatic, 633 were solid normal, and 8650 were from the primary tumor site. Each sample consisted of micro RNA expression data, available as RPM (reads per million mapped reads), as well as metadata including age and gender. We split TCGA data set into a combined primary tumor or solid normal samples training set and a metastatic sample test set.

Ananya Raghu, Anisha Raghu, Jillian F Wise

JMIR Bioinform Biotech 2024;5:e56538

Engaging Men of Diverse Racial and Ethnic Groups With Advanced Prostate Cancer in the Design of an mHealth Diet and Exercise Intervention: Focus Group Study

Engaging Men of Diverse Racial and Ethnic Groups With Advanced Prostate Cancer in the Design of an mHealth Diet and Exercise Intervention: Focus Group Study

Participants had metastatic hormone-sensitive prostate cancer if recruited from UCSF; we allowed participants in the community to have metastatic or nonmetastatic hormone-sensitive prostate cancer and did not verify metastasis status for these participants. Any man with any self-reported cognitive or neurologic condition that, in the opinion of the study team, would prohibit the ability to read and navigate the internet or follow a diet or exercise prescription independently were excluded.

Elizabeth Y Wang, Hala T Borno, Samuel L Washington III, Terence Friedlander, Sylvia Zhang, Evelin Trejo, Erin L Van Blarigan, June M Chan, Salma Shariff-Marco, Alexis L Beatty, Stacey A Kenfield

JMIR Cancer 2023;9:e45432

The Experiences of Patients With Adjuvant and Metastatic Melanoma Using Disease-Specific Social Media Communities in the Advent of Novel Therapies (Excite Project): Social Media Listening Study

The Experiences of Patients With Adjuvant and Metastatic Melanoma Using Disease-Specific Social Media Communities in the Advent of Novel Therapies (Excite Project): Social Media Listening Study

Surgery, while effective for early stages of melanoma, is a less effective treatment option for patients with metastatic or late-stage disease [7]. Newer therapies such as immunotherapy treatments and targeted therapies (TTs) have shown good efficacy in the treatment of metastatic melanoma and have shifted the treatment paradigm [8,9]. TTs block the growth and spread of cancer by interfering with specific molecules that are involved in the growth, spread, and progression of cancer.

Guy Faust, Alison Booth, Evie Merinopoulou, Sonia Halhol, Heena Tosar, Amir Nawaz, Magdalena Szlachetka, Gavin Chiu

JMIR Cancer 2022;8(2):e34073