A Machine Learning Approach for Predicting Biochemical Outcome After PSMA-PET–Guided Salvage Radiotherapy in Recurrent Prostate Cancer After Radical Prostatectomy: Retrospective Study

Ali Janbain   ¹ , PhD ;   Andrea Farolfi   ² , MD ;   Armelle Guenegou-Arnoux   ¹ , MSc, PHD ;   Louis Romengas   ¹ , MSc ;   Sophia Scharl   ³ , MD ;   Stefano Fanti   ² , MD ;   Francesca Serani   ² , MD ;   Jan C Peeken   ⁴ , MD ;   Sandrine Katsahian   ¹ , PHD ;   Iosif Strouthos   ⁵ , MD ;   Konstantinos Ferentinos   ⁵ , MD ;   Stefan A Koerber   ⁶ , MD ;   Marco E Vogel   ⁴ , MD ;   Stephanie E Combs   ⁴ , MD ;   Alexis Vrachimis   ⁵ , MD ;   Alessio Giuseppe Morganti   ⁷ , MD ;   Simon KB Spohn   ⁸ , MD ;   Anca-Ligia Grosu   ⁸ , MD ;   Francesco Ceci   ⁹ , MD ;   Christoph Henkenberens   ¹⁰ , MD ;   Stephanie GC Kroeze   ¹¹ , MD ;   Matthias Guckenberger   ¹¹ , MD ;   Claus Belka   ¹² , MD ;   Peter Bartenstein   ¹³ , MD ;   George Hruby   ¹⁴ , MD ;   Louise Emmett   ¹⁵ , MD ;   Ali Afshar Omerieh   ¹⁶ , MD ;   Nina-Sophie Schmidt-Hegemann   ¹⁷ , MD ;   Lucas Mose   ¹⁸ , MD ;   Daniel M Aebersold   ¹⁸ , MD ;   Constantinos Zamboglou   ⁵ , MD ;   Thomas Wiegel   ³ , MD ;   Mohamed Shelan   ¹⁸ , MD

¹ European Hospital Georges-Pompidou., Clinical research unit, INSERM Clinical Investigation Center., Paris Cité University, Paris, France

² Division of Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

³ Department of Radiation Oncology, University of Ulm, Ulm, Germany

⁴ Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany

⁵ Department of Radiation Oncology, German Oncology Center, University Hospital of the European University, Limassol, Cyprus

⁶ Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany

⁷ Division of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

⁸ Department of Radiation Oncology, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

⁹ Division of Nuclear Medicine, IEO European Institute of Oncology IRCCS, Milan, Italy

¹⁰ Department of Radiotherapy and Special Oncology, Medical School Hannover, Hannover, Germany

¹¹ Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland

¹² Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany

¹³ Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

¹⁴ Department of Radiation Oncology, Royal North Shore Hospital–University of Sydney, Sydney, Australia

¹⁵ Department of Theranostics and Nuclear Medicine, St Vincent’s Hospital Sydney, Sydney, Australia

¹⁶ Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

¹⁷ Department of Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, Switzerland

¹⁸ Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland