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Leveraging Patient-Reported Outcome Measures for Optimal Dose Selection in Early Phase Cancer Trials
Additionally, further safety data is gathered, and pharmacodynamic markers may also be developed.
Traditional early phase oncology dose-finding studies. RECIST: Response Evaluation Criteria in Solid Tumors.
This approach has been acceptable for cytotoxic chemotherapy drugs due to their steep dose-response relationships, their limited drug target specificity, and the willingness of patients to trade off substantial toxicity to treat serious, life-threatening diseases [2].
JMIR Cancer 2025;11:e64611
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In Silico Approaches to Polyherbal Synergy: Protocol for a Scoping Review
pharmacodynamic
JMIR Res Protoc 2024;13:e56646
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