Clinical Cancer Research

An Eye-Opening Approach: Cancer of Unknown Primary Source With Choroidal Metastasis Case Report

Erin Kaser, Vedin Barve, Alexander Blaschke, Constance Fry, Corey Waldman, Sarah Hackman, William Kelly

Interact J Med Res 2026 (Feb 05); 15:e77895

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Clinical Efficacy and Safety Assessment of Specific-Mode Electroacupuncture Stimulation Combined With Paclitaxel for Recurrent Malignant Gliomas: Study Protocol for a Single-Arm Trial

Zhaoxing Jia, Tianxiang Jiang, Yiqing Zhang, Qianyue Chen, Zhong Di, Qi Yuan, Kecheng Qian, Lin Gan, Congcong Ma, Xianming Lin

JMIR Res Protoc 2026 (Jan 29); 15:e84593

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Using Latent Dirichlet Allocation Topic Modeling to Uncover Latent Research Topics and Trends in Renal Cell Carcinoma: Bibliometric Review

Javier De La Hoz-M, Karime Montes-Escobar, Carlos Alfredo Salas-Macias, Martha Fors, Santiago J Ballaz

JMIR Cancer 2026 (Jan 16); 12:e78797

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Efficacy of an Ayurvedic Intervention as an Adjunct to Standard Care in Preventing Acute Pain Crises in Sickle Cell Anemia: Protocol for a Randomized Controlled Trial

U R Sekhar Namburi, Priya Thakare, Vaishali Kuchewar, Manish Deshmukh, Kalpana Kachare, Madhukar Tikas, Deepa Makhija, Bhogavalli Chandra Sekhara Rao, MN Suryawanshi, Satish Mahajan, Abha Sharma, N Srikanth, Ravinarayana Acharya

JMIR Res Protoc 2025 (Dec 31); 14:e76576

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IL-6/GP130/JAK/STAT3 Pathway Activation in Pancreatic Ductal Adenocarcinoma and Its Association With Clinical Features: Protocol for a Retrospective Cross-Sectional Study

Claudia Mellenthin, Fabien Schaller, Lucie Vignot, Sarah Peisl, Rita Vesce, Irene Esposito, Carmen Gonelle-Gispert, Cornelia Schneider, Michel Adamina, Leo Hans Bühler

JMIR Res Protoc 2025 (Dec 15); 14:e76811

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Effects of Aromatherapy on Chemotherapy-Induced Gastrointestinal Toxicity in Patients With Cancer: Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hongrui Shi, Xin Chen, Xinxin Fan, Mengqi Liu, Wei Peng, Wei Zou

JMIR Res Protoc 2025 (Dec 12); 14:e76350

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Evaluating a Clinical Decision Support Tool for Cancer Risk Assessment in Primary Care: Simulation Study of Unintended Weight Loss

Javiera Martinez-Gutierrez, Sophie Chima, Lucas De Mendonca, Alex Lee, Barbara Hunter, Jo-Anne Manski-Nankervis, Deborah Daly, George Fishman, Kit Huckvale, Fong Seng Lim, Benny Wang, Craig Nelson, Brian Nicholson, Jon Emery

JMIR Form Res 2025 (Dec 10); 9:e79208

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Quality of Life and Metabolomics Analysis in Response to Meal Kit Intervention During Perioperative Chemotherapy in Patients with Early-Stage Breast Cancer: Protocol for a Single-Center Phase Ⅱ Randomized Crossover Trial

Atsushi Fushimi, Eriko Taguchi, Makiko Kamio, Takashi Kazama, Azusa Fuke, Hiroko Nogi

JMIR Res Protoc 2025 (Dec 04); 14:e72715

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Knowledge of Clinical Trials Among US Cancer Survivors: Cross-Sectional Study of HINTS-SEER Data

Aisha Tene Langford, Katrina Renee Ellis, Nancy Buderer, Navreet Singh

JMIR Cancer 2025 (Nov 19); 11:e76187

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Efficacy of Preventive Pressurized Intraperitoneal Aerosol Chemotherapy in Patients With Locally Advanced Gastric Cancer: Protocol for a Prospective Controlled Trial

Altay Kerimkulov, Talgat Uskenbayev, Tomiris Sarina, Meiram Mamlin, Sanzhar Shalekenov, Gulfairus Yessenbayeva, Temirlan Kainazarov, Zhandos Burkitbayev, Baiduisen Ussipbekov, Dina Kovalchuk, Akhror Rakhmankulov, Aidana Rakhmankulova, Abduzhappar Gaipov

JMIR Res Protoc 2025 (Nov 11); 14:e78053

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Efficacy of Fuzheng Quxie Formula Against Postoperative Metastasis of Lung Cancer in Stage IIA-IIIA With Negative Driver Genes: Protocol for a Multicenter, Double-Blind, Randomized Controlled Trial

Fan Xu, Yun Yang, Yinbin Luo, Bin Luo, Jialiang Yao, Yiyang Zhou, Minghua Li, Jianchun Wu, Wenfei Shi, Lei Jiang, Qian Huang, Wentao Fang, Zhihong Fang, Yan Li, Jianhui Tian

JMIR Res Protoc 2025 (Oct 24); 14:e66342

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Impact of Immune Checkpoint Inhibitors on Second Primary Cancer Risk in Patients With Metastatic Lung Cancer Using Real-World Data From the TriNetX Network: Retrospective Cohort Study

Pierre Heudel, Gema Hernandez, Olivier Denquin, Hugo Crochet, Jean-Yves Blay

JMIR Cancer 2025 (Oct 21); 11:e64900

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Comparative Study of the Quality of Life of Patients With Ototoxicity Due to Platinum-Based Chemotherapy, With Hearing Aid Versus Those Without: Study Protocol for a Randomized Pilot Study—The PROTOTOX Study

Romina Mastronicola, Elise Kayser, Yolanda Fernandez, Gilles Dolivet

JMIR Res Protoc 2025 (Oct 10); 14:e71562

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Performance of Natural Language Processing for Information Extraction From Electronic Health Records Within Cancer: Systematic Review

Simon Dahl, Martin Bøgsted, Tomer Sagi, Charles Vesteghem

JMIR Med Inform 2025 (Sep 12); 13:e68707

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Machine Learning for Preoperative Assessment and Postoperative Prediction in Cervical Cancer: Multicenter Retrospective Model Integrating MRI and Clinicopathological Data

Shuqi Li, Chenyan Guo, Yufei Fang, Junjun Qiu, He Zhang, Lei Ling, Jie Xu, Xinwei Peng, Chuchu Jiang, Jue Wang, Keqin Hua

JMIR Cancer 2025 (Sep 12); 11:e69057

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Small Extracellular Vesicles as Biomarkers in Sarcoma Follow-Up: Protocol for a Prospective, Multicentric Pilot Study

Valentin Vautrot, Alice Hervieu, Aurélie Bertaut, Céline Charon-Barra, Isen Naiken, Sylvain Causseret, Loic Chaigneau, Isabelle Desmoulins, Emilie Rederstoff, Nicolas Isambert, Jessica Gobbo

JMIR Res Protoc 2025 (Sep 09); 14:e63718

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Automated Literature Screening for Hepatocellular Carcinoma Treatment Through Integration of 3 Large Language Models: Methodological Study

Chen Pan, Wei Lu, Bingliang Chen, Gang Zhang, Zhiming Yang, Jingcheng Hao

JMIR Med Inform 2025 (Sep 08); 13:e76252

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Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma: Protocol for a Pilot Randomized Controlled Trial

Yongle Zhan, Xiaohao Ruan, Yishuo Wu, Tsun Tsun Stacia Chun, Chi Yao, Ruofan Shi, Jiacheng Liu, Salida Ali, Ruochen Ma, Da Huang, Yi Gao, Ying Xu, Lu Chen, Qijun Du, Ada Tsui-Lin Ng, Cho Wing Bryan Li, Danfeng Xu, Rong Na

JMIR Res Protoc 2025 (Aug 26); 14:e72597

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Serum Alpha-Fetoprotein-Tumor Size Ratio as a Prognostic Marker After Hepatic Resection for Primary Hepatocellular Carcinoma: Propensity Score Matched Retrospective Cohort Study

Shutian Mo, Yongfei He, Tianyi Liang, Guangzhi Zhu, Hao Su, Chuangye Han, Tao Peng

JMIR Cancer 2025 (Aug 26); 11:e64929

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Implementation of Clinical Practice Guidelines to Prevent Cervical Cancer: Mixed Methods Study

Oliver C Ezechi, Folahanmi T Akinsolu, Olunike R Abodunrin, Oluwabukola M Ola, Chisom Obi-Jeff, Ishak K Lawal, George U Eleje, Joseph D Tucker, Juliet I Iwelunmor

JMIR Cancer 2025 (Aug 15); 11:e68572

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