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Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study

Novel Virtual Reality Intervention for Stress Reduction Among Patients With or at Risk for Cardiovascular Disease: Mixed Methods Pilot Study

VR has now demonstrated promise as a treatment modality for anxiety, phobias, depression, autism, and posttraumatic stress disorder as well as a way to aid in meditation [20-29]. Thus, VR is a potentially powerful tool to target stress reduction in patients with CVD.

Katherine E Makaroff, Christopher Van, Vincent Grospe, Lynae Edmunds, Marcella A Calfon-Press, Karol E Watson, Tamara Horwich

JMIR Cardio 2025;9:e66557

Effect of a Family-Centered Empowerment Model–Based Intervention on the Caregiving Capacity and Preparedness of Caregivers of Children With Malignant Neoplasms: Protocol for a Quasi-Experimental Study

Effect of a Family-Centered Empowerment Model–Based Intervention on the Caregiving Capacity and Preparedness of Caregivers of Children With Malignant Neoplasms: Protocol for a Quasi-Experimental Study

Additionally, the study aims to examine the effects of the empowerment intervention on caregivers’ self-efficacy as well as their levels of depression, anxiety, and stress. This study has the following research hypotheses: Statistically significant differences in caregiver preparedness and caregiving capacity will occur after the FCEM intervention program.

Xiaowan Li, Yanhua Yang, Qiurong Chen, JingJing Ma, Feng Lu, Xiaoli Luo

JMIR Res Protoc 2025;14:e73304

Just-in-Time Delivery of Cognitive Behavioral Therapy–Based Exercises: Single-Case Experimental Design With Random Multiple Baselines

Just-in-Time Delivery of Cognitive Behavioral Therapy–Based Exercises: Single-Case Experimental Design With Random Multiple Baselines

Furthermore, our pilot app was designed to offer different exercises according to the detected levels of stress. This tailoring was important because stress has intraindividual, temporal dynamics, and appropriate coping strategies may differ across the levels and types of stress [21,22]. It is not always possible for individuals to make a rational decision on how to cope with their stress.

Takeyuki Oba, Keisuke Takano, Daichi Sugawara, Kenta Kimura

JMIR Form Res 2025;9:e69556

Future Me, a Prospection-Based Chatbot to Promote Mental Well-Being in Youth: Two Exploratory User Experience Studies

Future Me, a Prospection-Based Chatbot to Promote Mental Well-Being in Youth: Two Exploratory User Experience Studies

These explored students’ stress experiences, coping strategies, and expectations from digital mental health tools. Participants discussed their stress management routines, daily stressors, responses to the Perceived Stress Scale (PSS)-10, and attitudes toward digital mental health tools and chatbots. After the first interviews, participants received instructions for using the Future Me chatbot.

Martin Dechant, Eva Lash, Sarah Shokr, Ciarán O'Driscoll

JMIR Form Res 2025;9:e74411

Kissing as a Protective Factor Against Decreased Salivary pH: Protocol for a Randomized Clinical Trial

Kissing as a Protective Factor Against Decreased Salivary pH: Protocol for a Randomized Clinical Trial

Reference 12: Romantic partner embraces reduce cortisol release after acute stress induction in women Reference 13: Kissing in marital and cohabiting relationships: effects on blood lipids, stress, and relationshipstress

Marcelo Armijos Briones, Mariuxi Aguila Gaibor, Andrea Bermúdez Velásquez

JMIR Res Protoc 2025;14:e65253

Feasibility of Digitally Identifying and Minimizing Stressors in Palliative Care Workplaces by Measuring Stress Continuously for Nurses Through Wearable Sensors (DiPa): Protocol for a Prospective Cross-Sectional Study

Feasibility of Digitally Identifying and Minimizing Stressors in Palliative Care Workplaces by Measuring Stress Continuously for Nurses Through Wearable Sensors (DiPa): Protocol for a Prospective Cross-Sectional Study

This serves to regulate stress reactions and prevent exhaustion of stress hormones. Only in chronic stress (eg, when the available resources are insufficient to relieve stress or when the stressor is present over a long period of time), a third phase, “exhaustion phase”, follows, with symptoms of exhaustion and a dangerous weakening of the immunological system [25]. The Di Pa study aims to test the feasibility of measuring and merging subjective and objective stress parameters in palliative care nurses.

Aaron Seehausen, Wencke Chodan, Florian Höpfner, Carolin Schneider, Sabine Felser, Hugo Murua Escobar, Mario Aehnelt, Christian Junghanss

JMIR Res Protoc 2025;14:e63549

Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study

Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study

Approximately 23.1% of US adults experience some form of diagnosable mental disorder [2], and 74% of US adults reported experiencing stress-related health issues within a given month [3], illustrating the widespread impact of anxiety-induced stress. Reliable biomarkers are essential for capturing the complexities of s-anxiety, enabling more precise and effective models.

Jadelynn Dao, Ruixiao Liu, Sarah Solomon, Samuel Aaron Solomon

JMIRx Med 2025;6:e69472

How Medical Students Manage Depression, Anxiety, and Stress: A Cross-Sectional Study

How Medical Students Manage Depression, Anxiety, and Stress: A Cross-Sectional Study

The survey comprised 2 demographic questions (school year and gender); 24 multiple-choice questions on stress management; 1 free-response question for any unlisted stress management activities and their frequency; and 21 randomly shuffled questions from the Depression, Anxiety and Stress Scale–21 Items (DASS-21) [7]. The hobbies listed were based on community observation. Data were analyzed using IBM SPSS Statistics (version 28.0.1.0). Normality was assessed via the Kolmogorov-Smirnov test.

Jonathan Shaw, Ashley Lai, Sasha Singh, Seung Rim Yoo, Maha Fathali, Laura Stuck, James Hagerty, Van Le, Jisu Shin, Charles Lai, Peter Bota, Aaron Jacobs

JMIR Form Res 2025;9:e74218