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Deep Phenotyping of Obesity: Electronic Health Record–Based Temporal Modeling Study

Deep Phenotyping of Obesity: Electronic Health Record–Based Temporal Modeling Study

Obesity affects approximately 40% of adults and 15%‐20% of children and adolescents in the United States [1,2]. It is projected that 49% of adults will have obesity, and 24.2% have severe obesity by 2030 in the USA [3]. Obesity increases the risk of a wide spectrum of chronic diseases and causes profound economic and psychosocial burden. Obesity arises from a complex interplay of genetic [4-7], nongenetic [8,9], and epigenetic factors [10-13].

Xiaoyang Ruan, Shuyu Lu, Liwei Wang, Andrew Wen, Sameer Murali, Hongfang Liu

J Med Internet Res 2025;27:e70140

Behavior Change Resources Used in Mobile App–Based Interventions Addressing Weight, Behavioral, and Metabolic Outcomes in Adults With Overweight and Obesity: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Behavior Change Resources Used in Mobile App–Based Interventions Addressing Weight, Behavioral, and Metabolic Outcomes in Adults With Overweight and Obesity: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Overweight and obesity are defined as excessive fat accumulation that can negatively affect health. People with a BMI between 25 and 30 kg/m2 are classified as overweight, while those with a BMI over 30 kg/m2 are classified as obese [1]. Overweight and obesity have become major public health issues. In 2016, more than 1.9 billion adults were overweight, with approximately 650 million experiencing obesity [2], and this number is estimated to affect half of the global population by 2030 [3].

Sijia Li, You Zhou, Ying Tang, Haoming Ma, Yuying Zhang, Aoqi Wang, Xingyi Tang, Runyuan Pei, Meihua Piao

JMIR Mhealth Uhealth 2025;13:e63313

A Virtual Simulator to Improve Weight-Related Communication Skills for Health Care Professionals: Mixed Methods Pre-Post Pilot Feasibility Study

A Virtual Simulator to Improve Weight-Related Communication Skills for Health Care Professionals: Mixed Methods Pre-Post Pilot Feasibility Study

Obesity is a leading contributor to chronic disease and reduced quality of life [1,2]; yet, weight remains a sensitive and often avoided topic in clinical settings [3,4]. Despite national and global policy goals and clinical guidelines calling for earlier, more compassionate intervention [5-7], many health care professionals (HCPs) report inadequate training, lack of confidence, and fear of damaging the patient relationship when discussing weight [8-11].

Fiona Quigley, Leona Ryan, Raymond Bond, Toni McAloon, Huiru Zheng, Anne Moorhead

JMIR Med Educ 2025;11:e65949

Prevalence of Chronic Back Pain and Associated Factors in Children and Adolescents: Secondary Analysis of the 2001–2019 Health Behavior in School-Aged Children Study

Prevalence of Chronic Back Pain and Associated Factors in Children and Adolescents: Secondary Analysis of the 2001–2019 Health Behavior in School-Aged Children Study

It should be mentioned, in the 2017‐2019 wave, BMI classification adhered to the standards outlined by the International Obesity Task Force [20] (1=thinness, 2=normal weight, 3=overweight, 4=obesity). For further analysis, excess weight (ie, overweight or obesity) was determined as follows: 0=no excess weight (ie, thinness or normal weight); 1=excess weight (ie, overweight or obesity).

Camila Miño, Héctor Gutiérrez-Espinoza, Jorge Olivares-Arancibia, Rodrigo Yáñez-Sepúlveda, Daniel Duclos-Bastías, Felipe Araya-Quintanilla, Lee Smith, José Francisco López-Gil

JMIR Public Health Surveill 2025;11:e67960

“Digital Clinicians” Performing Obesity Medication Self-Injection Education: Feasibility Randomized Controlled Trial

“Digital Clinicians” Performing Obesity Medication Self-Injection Education: Feasibility Randomized Controlled Trial

Obesity, an “abnormal or excessive accumulation of fat that poses a health risk” [1], is a primary contributor to global health challenges [2]. Reports suggest its involvement in up to 80% of cases of type 2 diabetes and 43% of cardiovascular incidents [3] while significantly contributing to depression and anxiety [4]. Recent breakthroughs in bariatric medicine have elevated the role of injectable therapy, namely glucagon-like peptide-1 agonist agents such as semaglutide.

Sean Coleman, Caitríona Lynch, Hemendra Worlikar, Emily Kelly, Kate Loveys, Andrew J Simpkin, Jane C Walsh, Elizabeth Broadbent, Francis M Finucane, Derek O' Keeffe

JMIR Diabetes 2025;10:e63503

Feasibility and Acceptability of a Psychological Intervention for Internalized Health-Related Stigma Among Adults With Chronic Health Conditions: Preliminary Investigation

Feasibility and Acceptability of a Psychological Intervention for Internalized Health-Related Stigma Among Adults With Chronic Health Conditions: Preliminary Investigation

For example, adults with obesity, type 1 or type 2 diabetes, skin diseases, HIV, chronic pain, and cancers face pervasive stigma for their health conditions [1,4-6]. In addition to experiencing stigma from other people, negative attitudes can be internalized by adults with these health conditions, contributing to self-blame and self-devaluation (ie, self-stigma) [7,8].

Rebecca L Pearl, Danielle Saunders, Laurie C Groshon, Yulin Li, Abigail Shonrock, Rebecca M Puhl, Kimberly A Driscoll, Preeti Manavalan, Joel M Gelfand, Thomas A Wadden, Sarah C Westen, Marjorie Montanez-Wiscovich, Xiang-Yang Lou

JMIR Form Res 2025;9:e69548

Effects of Therapeutic Ultrasound and Aussie Current With High-Intensity Interval Training on Abdominal Adiposity in Young Adults With Overweight and Obesity: Protocol for a Randomized Controlled Trial

Effects of Therapeutic Ultrasound and Aussie Current With High-Intensity Interval Training on Abdominal Adiposity in Young Adults With Overweight and Obesity: Protocol for a Randomized Controlled Trial

According to a report by the World Obesity Federation, more than half of the world’s population will be overweight or obese by 2035 [1]. Excess abdominal fat is a primary determinant for developing insulin resistance and other metabolic disorders [2]. Lifestyle modification is the most recommended approach for treating and preventing obesity at any stage of life [2].

Ana Carolina Aparecida Marcondes-Scalli, Patricia Rehder-Santos, Étore De Favari Signini, Alex Castro, Carla Dato, Leonardo Furlan, Richard Eloin Liebano, Aparecida Maria Catai

JMIR Res Protoc 2025;14:e71829

Effect of Minimal Individual or Group Enhancement in an eHealth Program on Mental Health, Health Behavior, and Work Ability in Employees With Obesity: Randomized Controlled Trial

Effect of Minimal Individual or Group Enhancement in an eHealth Program on Mental Health, Health Behavior, and Work Ability in Employees With Obesity: Randomized Controlled Trial

Obesity and mental health problems are intricately connected, with evidence suggesting a bidirectional relationship between the two [1,2]. Depression, one of the most extensively studied mental health issues, increases the risk of obesity by 58%, while obesity elevates the risk of depression by 55% [3]. Furthermore, both obesity and depression are significant risk factors for reduced work ability [4,5], and occupational burnout has been linked to these conditions [6-8].

Siniriikka A Männistö, Joona Muotka, Laura-Unnukka Suojanen, Raimo Lappalainen, Kirsi H Pietiläinen, Riitta Korpela

JMIR Ment Health 2025;12:e66518

A Remotely Delivered GLP-1RA–Supported Specialist Weight Management Program in Adults Living With Obesity: Retrospective Service Evaluation

A Remotely Delivered GLP-1RA–Supported Specialist Weight Management Program in Adults Living With Obesity: Retrospective Service Evaluation

Obesity remains a global health crisis, affecting 890 million adults worldwide and contributing to diseases such as type 2 diabetes, cardiovascular disease, and certain cancers [1]. In the United Kingdom, projections suggest that by 2050, the annual cost of obesity to the National Health Service (NHS) could reach £9.7 billion (US $12.1 billion), with wider societal expenses approaching £49.9 billion (US $62.4 billion) [2].

Rebecca Richards, Michael Whitman, Gina Wren, Peta Campion

JMIR Form Res 2025;9:e72577

Virtual Reality in Obesity Management: Addressing Key Limitations in Clinical Application

Virtual Reality in Obesity Management: Addressing Key Limitations in Clinical Application

We are writing to express our appreciation for the recent publication in the Journal of Medical Internet Research titled “Assessing the Clinical Efficacy of a Virtual Reality Tool for the Treatment of Obesity: Randomized Controlled Trial” [1]. The authors propose an innovative approach to obesity treatment that leverages the interactivity and immersive experience of virtual reality (VR) technology through a randomized controlled trial, providing new scientific evidence for obesity management.

Xin Hu, Bin Wei

J Med Internet Res 2025;27:e68269