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Patient and Provider Perspectives of a Web-Based Intervention to Support Symptom Management After Radioactive Iodine Treatment for Differentiated Thyroid Cancer: Qualitative Study

Patient and Provider Perspectives of a Web-Based Intervention to Support Symptom Management After Radioactive Iodine Treatment for Differentiated Thyroid Cancer: Qualitative Study

Thyroid cancer is often mislabeled as the “good cancer” [1-3] due to the excellent 5-year survival rates compared to other cancers [4]. Differentiated thyroid cancer (DTC) is the most common endocrine malignancy among the estimated 44,020 new cases of thyroid cancer in the United States annually [4]. DTC involves a spectrum of disease presentations characterized by different levels of risk of recurrence.

Alaina L Carr, Angela M Jenkins, Jacqueline Jonklaas, Kate Gabriel, Kristen E Miller, Kristi D Graves

JMIR Form Res 2025;9:e60588

Automated Process for Monitoring of Amiodarone Treatment: Development and Evaluation

Automated Process for Monitoring of Amiodarone Treatment: Development and Evaluation

However, careful follow-up is necessary during treatment due to potentially serious adverse effects and toxic reactions in the thyroid gland, liver, lung, and heart. Approximately 15% of patients will experience adverse effects during the first year of amiodarone use and 50% during long-term treatment, most often thyroid and liver dysfunction [1].

Birgitta I Johansson, Jonas Landahl, Karin Tammelin, Erik Aerts, Christina E Lundberg, Martin Adiels, Martin Lindgren, Annika Rosengren, Nikolaos Papachrysos, Helena Filipsson Nyström, Helen Sjöland

J Med Internet Res 2025;27:e65473

Peer Review for “Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis”

Peer Review for “Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis”

This is the peer-review report for “Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis.”

Anonymous

JMIRx Med 2024;5:e59120

Authors’ Response to Peer Reviews of “Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis”

Authors’ Response to Peer Reviews of “Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis”

This is the authors’ response to peer-review reports for “Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis.”

Tigran Makunts, Haroutyun Joulfayan, Ruben Abagyan

JMIRx Med 2024;5:e58273

Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis

Thyroid Hyperplasia and Neoplasm Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists in the Food and Drug Administration Adverse Event Reporting System: Retrospective Analysis

Of a greater concern are the labeled boxed warnings of liraglutide, semaglutide, and dulaglutide, marking these as contraindicated in patients with a family history of medullary thyroid carcinoma. These warnings were based on nonhuman data about the development of thyroid C-cell tumors in rats and mice receiving clinically relevant doses of GLP-1 RAs [15-17]. The thyroid cancer association in humans has been studied and observed as well in retrospective studies [18-20].

Tigran Makunts, Haroutyun Joulfayan, Ruben Abagyan

JMIRx Med 2024;5:e55976

Identification and Management of Thyroid Dysfunction Using At-Home Sample Collection and Telehealth Services: Retrospective Analysis of Real-World Data

Identification and Management of Thyroid Dysfunction Using At-Home Sample Collection and Telehealth Services: Retrospective Analysis of Real-World Data

According to the American Thyroid Association, nearly 20 million Americans currently have some form of thyroid disease, and over 12% of individuals in the United States will develop a thyroid condition within their lifetime [7]. It is common for patients to request specific tests from their physicians [8-10]. More recently, commercial avenues have become available for consumers to pursue testing.

Kathleen M Gavin, Daniel Kreitzberg, Yvette Gaudreau, Marisa Cruz, Timothy A Bauer

J Med Internet Res 2023;25:e43707

Explainable Machine Learning Techniques To Predict Amiodarone-Induced Thyroid Dysfunction Risk: Multicenter, Retrospective Study With External Validation

Explainable Machine Learning Techniques To Predict Amiodarone-Induced Thyroid Dysfunction Risk: Multicenter, Retrospective Study With External Validation

Amiodarone-induced thyroid dysfunction (AITD) is a common, irreversible, and unpredictable adverse thyroid effect, leading to therapy failure and significant mortality. As it is the drug of choice for arrhythmias and atrial fibrillation, developing predictive models for the early detection of AITD is warranted [1-4]. The incidence of AITD varies with iodine intake and ranges from 17% to 30% [5-7].

Ya-Ting Lu, Horng-Jiun Chao, Yi-Chun Chiang, Hsiang-Yin Chen

J Med Internet Res 2023;25:e43734

Seasonality of Hashimoto Thyroiditis: Infodemiology Study of Google Trends Data

Seasonality of Hashimoto Thyroiditis: Infodemiology Study of Google Trends Data

The leading cause of hypothyroidism, in areas with sufficient iodine intake, is Hashimoto thyroiditis (HT)—an autoimmune thyroid disease, with an incidence of 0.3-0.5 of 1000 population per year [2]. HT can present with a long list of both local and systematic symptoms such as dyspnea, dysphagia, dysphonia, constipation, coronary artery disease, bradycardia, anemia, memory loss, depression, bile colic, and dry and thickened skin [3].

Robert Marcec, Josip Stjepanovic, Robert Likic

JMIR Bioinform Biotech 2022;3(1):e38976

Automatic Classification of Thyroid Findings Using Static and Contextualized Ensemble Natural Language Processing Systems: Development Study

Automatic Classification of Thyroid Findings Using Static and Contextualized Ensemble Natural Language Processing Systems: Development Study

Thyroid glands are butterfly-shaped endocrine glands located in the lower front of the neck and are responsible for the production of thyroid hormone [24]. Thyroid nodules are lumps produced by abnormal growth of thyroid cells that appear as either solid (hard lumps) or cystic (water lumps). If nodules are found in the thyroid gland during a medical examination, thyroid ultrasonography can be performed to check for signs of cancer.

Dongyup Shin, Hye Jin Kam, Min-Seok Jeon, Ha Young Kim

JMIR Med Inform 2021;9(9):e30223