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Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

At the time of analysis, the program has recruited 59,352 individuals, returned 33,142 results, and identified 132 individuals with Lynch syndrome, 265 individuals with hereditary breast and ovarian cancer syndrome, and 191 individuals with familial hypercholesterolemia. LLM models have been applied to improve accuracy and standardization for a variety of biomedical tasks including medical guidelines retrieval, diagnostics, medical reporting, and medical education [38-40].

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848

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Establishing Syndromic Surveillance of Acute Coronary Syndrome, Myocardial Infarction, and Stroke: Registry Study Based on Routine Data From German Emergency Departments

Therefore, a significant challenge when implementing new indicators into an established surveillance system lies in determining the ability of specific syndrome definitions to sufficiently detect cases of the respective indicator. This study therefore aimed to develop and validate the syndrome definitions for the monitoring of acute coronary syndrome (ACS), MI, and STR, and to assess their potential for a future integration into the RKI’s routine ED surveillance.

Madlen Schranz, Mirjam Rupprecht, Annette Aigner, Leo Benning, Carmen Schlump, Nesrine Charfeddine, Michaela Diercke, Linus Grabenhenrich, Alexander Ullrich, Hannelore Neuhauser, Birga Maier, AKTIN Research Group, Felix Patricius Hans, Sabine Blaschke