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Authors’ Response to Peer Reviews of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

Authors’ Response to Peer Reviews of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

Response: We agree with this suggestion and have added two new tables to present our results more clearly: Table 1: Demographic and clinical characteristics of childhood cancer survivors (page 9). Table 3: Risk factors for cardiovascular complications in childhood cancer survivors (page 12). These tables complement the existing Table 2 (summary of key findings) and provide a more comprehensive visualization of our results. 2.

Masab Mansoor, Andrew Ibrahim

JMIRx Med 2025;6:e79672

Peer Review of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

Peer Review of “Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study”

This significant and timely manuscript [1], which investigates the long-term cardiovascular complications in pediatric cancer survivors, has notable strengths, including its large cohort size, long-term follow-up, and utilization of a well-established dataset (Childhood Cancer Survivor Study). The methodology is generally sound, and the findings contribute meaningfully to our understanding of cardiotoxicity risks in childhood cancer survivors.

John Lucas Jr

JMIRx Med 2025;6:e79523

Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study

Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study

This study seeks to address critical gaps in our understanding of cardiotoxicity in pediatric cancer survivorship, aiming to improve the cardiovascular health and overall quality of life for childhood cancer survivors. The primary aim of this study is to comprehensively investigate cardiotoxicity in pediatric cancer survivors using data from the Childhood Cancer Survivor Study (CCSS; Textbox 1).

Masab Mansoor, Andrew Ibrahim

JMIRx Med 2025;6:e65299

Oncology Provider and Patient Perspectives on a Cardiovascular Health Assessment Tool Used During Posttreatment Survivorship Care in Community Oncology (Results from WF-1804CD): Mixed Methods Observational Study

Oncology Provider and Patient Perspectives on a Cardiovascular Health Assessment Tool Used During Posttreatment Survivorship Care in Community Oncology (Results from WF-1804CD): Mixed Methods Observational Study

Survivors of many common early-stage cancers are now more likely to die of cardiovascular disease than cancer, elevating the importance of addressing cardiovascular health (CVH) in routine survivorship care [1-6]. Over 90% of survivors have multiple cardiovascular risk factors [7], increasing their risk of both poor cardiovascular and cancer outcomes [8-16]. Compared to the general population, survivors of cancer have poorer CVH [17,18].

Chandylen L Nightingale, Emily V Dressler, Maura Kepper, Heidi D Klepin, Simon Craddock Lee, Sydney Smith, Aylin Aguilar, Kimberly D Wiseman, Stephanie J Sohl, Brian J Wells, Joseph A DeMari, Alyssa Throckmorton, Lindsey W Kulbacki, Jenny Hanna, Randi E Foraker, Kathryn E Weaver

J Med Internet Res 2025;27:e65152

Adapting a Self-Guided eHealth Intervention Into a Tailored Therapist-Guided eHealth Intervention for Survivors of Colorectal Cancer

Adapting a Self-Guided eHealth Intervention Into a Tailored Therapist-Guided eHealth Intervention for Survivors of Colorectal Cancer

However, no intervention customized to address FCR in survivors of CRC has been developed [7,41]. In summary, this paper describes the process of adapting i Conquer Fear into TG-i Conquer Fear targeting survivors of CRC.

Johanne Dam Lyhne, Allan Ben Smith, Tina Birgitte Wisbech Carstensen, Lisa Beatty, Adeola Bamgboje-Ayodele, Britt Klein, Lars Henrik Jensen, Lisbeth Frostholm

JMIR Cancer 2025;11:e63486

Measuring Relationship Influences on Romantic Couples’ Cancer-Related Behaviors During the COVID-19 Pandemic: Protocol for a Longitudinal Online Study of Dyads and Cancer Survivors

Measuring Relationship Influences on Romantic Couples’ Cancer-Related Behaviors During the COVID-19 Pandemic: Protocol for a Longitudinal Online Study of Dyads and Cancer Survivors

In addition, cancer survivors have been particularly vulnerable to COVID-19 during the pandemic [16]. The greater risk of health consequences for cancer survivors due to the COVID-19 pandemic, combined with evidence gaps in the existing survivorship literature [17], demonstrates a critical need to better understand the mechanisms of health behavior and risk perceptions during survivorship.

Jennifer M Bowers, Chloe O Huelsnitz, Laura A Dwyer, Laurel P Gibson, Tanya Agurs-Collins, Rebecca A Ferrer, Amanda M Acevedo

JMIR Res Protoc 2024;13:e48516

Behavioral Weight Loss Programs for Cancer Survivors Throughout Maryland: Protocol for a Pragmatic Trial and Participant Characteristics

Behavioral Weight Loss Programs for Cancer Survivors Throughout Maryland: Protocol for a Pragmatic Trial and Participant Characteristics

Hence, for many cancer survivors, obesity poses a dual risk of decreased cardiometabolic health and increased cancer recurrence. In the United States, there were an estimated 18 million cancer survivors in 2022 [7], and this number is expected to increase to 22.5 million by 2032 due to advancements in treatment and early detection [8]. It is estimated that 32.5% of cancer survivors are overweight or obese [7].

Gerald J Jerome, Lawrence J Appel, Linda Bunyard, Arlene T Dalcin, Nowella Durkin, Jeanne B Charleston, Norma F Kanarek, Michael A Carducci, Nae-Yuh Wang, Hsin-Chieh Yeh

JMIR Res Protoc 2024;13:e54126

Risk of Subsequent Primary Cancers Among Adult-Onset 5-Year Cancer Survivors in South Korea: Retrospective Cohort Study

Risk of Subsequent Primary Cancers Among Adult-Onset 5-Year Cancer Survivors in South Korea: Retrospective Cohort Study

Characteristics of survivors diagnosed with a first primary cancer in 2009-2010 at age ≥18 years among 5-year survivors in South Korea. Risk of developing any type of subsequent primary cancer (SPC) among 5-year cancer survivors with their first diagnosis between 2009 and 2010 in South Korea. a SIR: standardized incidence ratio. b FPC: first primary cancer.

Yoon Young Choi, Myeongjee Lee, Eun Hwa Kim, Jae Eun Lee, Inkyung Jung, Jae-Ho Cheong

JMIR Public Health Surveill 2024;10:e48380

Supporting Life Adjustment in Patients With Lung Cancer Through a Comprehensive Care Program: Protocol for a Controlled Before-and-After Trial

Supporting Life Adjustment in Patients With Lung Cancer Through a Comprehensive Care Program: Protocol for a Controlled Before-and-After Trial

Consequently, the growing number of lung cancer survivors underscores the urgent need to address posttreatment needs. Surviving lung cancer can substantially impact the quality of life and emotional health [4-6]. Many survivors adjust over time; however, persistent fear and the expectation of a rapid return to normal posttreatment life are common [7,8].

Wonyoung Jung, Alice Ahn, Genehee Lee, Sunga Kong, Danbee Kang, Dongok Lee, Tae Eun Kim, Young Mog Shim, Hong Kwan Kim, Jongho Cho, Juhee Cho, Dong Wook Shin

JMIR Res Protoc 2024;13:e54707