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Assisted Reproductive Technology and Risk of Childhood Cancer Among the Offspring of Parents With Infertility: Systematic Review and Meta-Analysis

Assisted Reproductive Technology and Risk of Childhood Cancer Among the Offspring of Parents With Infertility: Systematic Review and Meta-Analysis

The inclusion criteria were constructed using the PICOS (Population, Intervention, Comparison, Outcomes, and Study Design) framework: Population: infertile or subfertile couples. Intervention: ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), FET, and fresh-ET. Comparison: non-ART, defined as infertile or subfertile couples who did not conceive through ART but may have conceived naturally or with induced ovulation induction (OI) or intrauterine insemination (IUI).

Gao Song, Cai-qiong Zhang, Zhong-ping Bai, Rong Li, Meng-qun Cheng

JMIR Cancer 2025;11:e65820