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Skip search results from other journals and go to results- 1 JMIR Cancer
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Inhibiting HMG-Co A (3-hydroxy-3-methylglutaryl-coenzyme A) reductase (HMGR) is a key therapeutic strategy for managing hypercholesterolemia, with statins serving as the most widely used competitive inhibitors; however, their prolonged use is associated with adverse effects. This study aims to identify novel, natural inhibitors of HMGR as potential alternatives to statins.
JMIRx Bio 2025;3:e74084
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Inclusion criteria were hypercholesterolemia (total cholesterol ≥5.0 mmol/L), diabetes mellitus (preexisting or hemoglobin A1c [Hb A1c] ≥6.5%), BMI ≤18.5 or ≥30 kg/m², not reaching the recommended activity time (
These inclusion criteria were based on three different perspectives on who would benefit most from counseling: the perspective of the survivor (expresses the need for counseling), the perspective of the sports scientist (focus on activity level and anthropometric data), and the perspective of the treating
JMIR Cancer 2024;10:e59614
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As with other CVD risk factors, genetic risk plays a role in the development of dyslipidemia, such as in familial hypercholesterolemia; however, the majority of cases are due to unhealthy lifestyle behaviors [5,6]. As such, lifestyle interventions are central to dyslipidemia prevention and are recommended for all patients before pharmacotherapy is prescribed, and even after pharmacotherapy initiation [5].
JMIR Cardio 2022;6(1):e34946
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Hypertension, diabetes, and hypercholesterolemia are the global leading risks of cardiovascular mortality [1-3]. Health behaviors such as engaging in exercise, balanced diet, and weight control reduce one’s risk of cardiovascular mortality. Therefore, in addition to medication, the management of health behavior is crucial in patients with multiple risks of cardiovascular mortality [4].
J Med Internet Res 2020;22(1):e15057
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