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Implementing Large Language Models in Health Care: Clinician-Focused Review With Interactive Guideline

Implementing Large Language Models in Health Care: Clinician-Focused Review With Interactive Guideline

Numbers 1 to 8 represent clinical task categories. One might wish for a generalist clinical LLM acting as an intelligent hub, as envisioned by Moor et al [15] in their concept of generalist medical AI. Such LLMs do not require model parameter updates to perform various clinical tasks but might be required to be trained or fine-tuned using specialized clinical medical knowledge.

HongYi Li, Jun-Fen Fu, Andre Python

J Med Internet Res 2025;27:e71916

Ecological Momentary Assessment of the Quality of Life and Self-Efficacy Among People With a Stoma: Longitudinal Study

Ecological Momentary Assessment of the Quality of Life and Self-Efficacy Among People With a Stoma: Longitudinal Study

At baseline, participants were sent a link to a survey to complete demographic and clinical characteristic measures. After this was completed, they were then sent step-by-step instructions on how to download and register for the Avicenna Research app (formerly Ethica Data app) on their smartphone. Surveys were programmed to be sent to participants at 9 AM, 1 PM, and 7 PM to provide a view of participants’ quality of life over the course of the day.

William Goodman, Matthew Allsop, Amy Downing, Julie Munro, Gill Hubbard, Rebecca J Beeken

J Med Internet Res 2025;27:e57427

Global Health care Professionals’ Perceptions of Large Language Model Use In Practice: Cross-Sectional Survey Study

Global Health care Professionals’ Perceptions of Large Language Model Use In Practice: Cross-Sectional Survey Study

In medicine, recent studies have demonstrated Chat GPT’s potential to support clinical decision-making, summarize complex medical data, and streamline documentation processes. For instance, Chat GPT has been evaluated for its ability to generate discharge summaries, assist in developing differential diagnoses, and simplify patient communication [3-5].

Ecem Ozkan, Aysun Tekin, Mahmut Can Ozkan, Daniel Cabrera, Alexander Niven, Yue Dong

JMIR Med Educ 2025;11:e58801

Impact on Patient Outcomes of Continuous Vital Sign Monitoring on Medical Wards: Propensity-Matched Analysis

Impact on Patient Outcomes of Continuous Vital Sign Monitoring on Medical Wards: Propensity-Matched Analysis

Aggregate VS scoring systems such as the early warning score (EWS) have been developed to aid in the identification and risk stratification of patients at risk of or experiencing clinical deterioration. Once identified, clinical response teams, often termed “rapid response teams” (RRTs), may intervene to provide stabilization or transfer to a higher level of care. This identification and response have been described as the afferent and efferent arms, respectively, of rapid response [16].

Bradley Rowland, Amit Saha, Vida Motamedi, Richa Bundy, Scott Winsor, Daniel McNavish, William Lippert, Ashish K Khanna

J Med Internet Res 2025;27:e66347

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

This approach is limited by several clinical misconceptions and assumptions: first, the most efficacious anti–heart failure therapies were developed first. The counterargument is exemplified by the fact that digitalis has been used in clinical practice for 200 years, yet it is no longer considered a key therapeutic agent. Second, drug efficacy is only achieved at maximum target doses [1].

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025;14:e44027

Generative AI–Enabled Therapy Support Tool for Improved Clinical Outcomes and Patient Engagement in Group Therapy: Real-World Observational Study

Generative AI–Enabled Therapy Support Tool for Improved Clinical Outcomes and Patient Engagement in Group Therapy: Real-World Observational Study

Therefore, our results suggest that the AI-enabled therapy support tool may improve individual patients’ outcomes and support clinical services by increasing treatment adherence and treatment effectiveness. We evaluated the efficacy of an AI-enabled therapy support tool (Limbic Care; Limbic Ltd [25]) in a real-world clinical context in 5 NHS Talking Therapies for anxiety and depression services provided by Everyturn Mental Health in the United Kingdom.

Johanna Habicht, Larisa-Maria Dina, Jessica McFadyen, Mona Stylianou, Ross Harper, Tobias U Hauser, Max Rollwage

J Med Internet Res 2025;27:e60435

Kangaroo Stimulation Game in Tracheostomized Intensive Care–Related Dysphagia: Interventional Feasibility Study

Kangaroo Stimulation Game in Tracheostomized Intensive Care–Related Dysphagia: Interventional Feasibility Study

Patients were decannulated based on clinical observations made by registered nurses and assessments by SLPs. Two patients died during the ICU admission, not related to swallowing abnormalities. Patient characteristicsa. a Variables with a normal distribution are described as mean (SD) and variables with a nonnormal distribution are described as median (IQR).

Marjolein Jansen, Ingrid D van Iperen, Anke Kroner, Raphael Hemler, Esther Dekker-Holverda, Peter E Spronk

JMIR Serious Games 2025;13:e60685

Identification of Gender Differences in Acute Myocardial Infarction Presentation and Management at Aga Khan University Hospital-Pakistan: Natural Language Processing Application in a Dataset of Patients With Cardiovascular Disease

Identification of Gender Differences in Acute Myocardial Infarction Presentation and Management at Aga Khan University Hospital-Pakistan: Natural Language Processing Application in a Dataset of Patients With Cardiovascular Disease

A promising direction is the use of electronic health records (EHRs) to analyze patient data to better inform clinical decision-making and assess adherence to IHD treatment guidelines using a gender lens. However, the wealth of existing data in clinical records is generally inaccessible in LMICs as it exists in the form of free-text clinical narratives, as patient discharge summaries and hospital admission notes, and these are often handwritten [10,11].

Christine Ngaruiya, Zainab Samad, Salma Tajuddin, Zarmeen Nasim, Rebecca Leff, Awais Farhad, Kyle Pires, Muhammad Alamgir Khan, Lauren Hartz, Basmah Safdar

JMIR Form Res 2024;8:e42774

Performance of ChatGPT in Ophthalmic Registration and Clinical Diagnosis: Cross-Sectional Study

Performance of ChatGPT in Ophthalmic Registration and Clinical Diagnosis: Cross-Sectional Study

Further validation studies, particularly in testing Chat GPT’s diagnostic effectiveness for a comprehensive range of eye diseases within the context of clinical practice in China, are essential. Drawing on typical clinical cases from Chinese Standardized Resident Training (SRT) materials, this study aims to evaluate Chat GPT’s capacity for classifying ophthalmic subspecialties and its diagnostic potential within the Chinese context.

Shuai Ming, Xi Yao, Xiaohong Guo, Qingge Guo, Kunpeng Xie, Dandan Chen, Bo Lei

J Med Internet Res 2024;26:e60226

Interest in the Use of Herbal Supplements to Close the Treatment Gap for Hazardous Alcohol Use Among Men Who Have Sex With Men: Secondary Analysis of a Cross-Sectional Study

Interest in the Use of Herbal Supplements to Close the Treatment Gap for Hazardous Alcohol Use Among Men Who Have Sex With Men: Secondary Analysis of a Cross-Sectional Study

Participants were also asked about their demographic, clinical, and behavioral history. Questions assessing interest in reducing alcohol consumption, interest in pharmacotherapy, and interest in herbal supplements had 4 response options: not interested, somewhat interested, moderately interested, and extremely interested.

Christopher Hernandez, Christopher Rowe, Janet Ikeda, Justine Arenander, Glenn-Milo Santos

JMIR Form Res 2024;8:e60370