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Design and Validation of a Chatbot-Based Cervical Cancer Screening Decision Aid for Women Experiencing Socioeconomic Disadvantage: User-Centered Approach Study

Design and Validation of a Chatbot-Based Cervical Cancer Screening Decision Aid for Women Experiencing Socioeconomic Disadvantage: User-Centered Approach Study

The findings from this phase informed the initial design of the chatbot. Phase 2: prototype testing (June 2023 to July 2023)—this phase corresponded to the “alpha testing” step in the framework. We tested the chatbot prototype with both eligible women and health care professionals, gathering feedback on usability, content design, content comprehension, and acceptability.

Alice Le Bonniec, Catherine Sauvaget, Eric Lucas, Abdelhak Nassiri, Farida Selmouni

JMIR Cancer 2025;11:e70251

Perceptions and Attitudes of Chinese Oncologists Toward Endorsing AI-Driven Chatbots for Health Information Seeking Among Patients with Cancer: Phenomenological Qualitative Study

Perceptions and Attitudes of Chinese Oncologists Toward Endorsing AI-Driven Chatbots for Health Information Seeking Among Patients with Cancer: Phenomenological Qualitative Study

Oncologists were uncertain about who would bear responsibility if patients experienced adverse outcomes after following chatbot recommendations. This led to hesitation in endorsing or recommending them in clinical practice. For certain, liability is the biggest concern. If a patient follows advice given by AI and something goes wrong, who will be held responsible?

Lijuan Zeng, Qiaoqi Li, Yan Zuo, Ying Zhang, Zhaojun Li

J Med Internet Res 2025;27:e71418

DigiBete, a Novel Chatbot to Support Transition to Adult Care of Young People/Young Adults With Type 1 Diabetes Mellitus: Outcomes From a Prospective, Multimethod, Nonrandomized Feasibility and Acceptability Study

DigiBete, a Novel Chatbot to Support Transition to Adult Care of Young People/Young Adults With Type 1 Diabetes Mellitus: Outcomes From a Prospective, Multimethod, Nonrandomized Feasibility and Acceptability Study

With safety in mind, the chatbot was preloaded with clinically approved, pedestrianized responses to questions and queries, which were necessary to ensure the user’s safety while using the chatbot. The scope of the chatbot was limited to the resources on the website only [16], to ensure the clinical accuracy and safety of the resources that the chatbot would surface for the user.

Veronica Swallow, Janet Horsman, Eliza Mazlan, Fiona Campbell, Reza Zaidi, Madeleine Julian, Jacob Branchflower, Jackie Martin-Kerry, Helen Monks, Astha Soni, Alison Rodriguez, Rob Julian, Paul Dimitri

JMIR Diabetes 2025;10:e74032

Future Me, a Prospection-Based Chatbot to Promote Mental Well-Being in Youth: Two Exploratory User Experience Studies

Future Me, a Prospection-Based Chatbot to Promote Mental Well-Being in Youth: Two Exploratory User Experience Studies

Few studies have explored on-demand, chatbot-based interventions that incorporate prospection-based techniques, particularly for student populations who may benefit significantly from improved future-oriented thinking.

Martin Dechant, Eva Lash, Sarah Shokr, Ciarán O'Driscoll

JMIR Form Res 2025;9:e74411

Evaluating the Usability of an HIV Prevention Artificial Intelligence Chatbot in Malaysia: National Observational Study

Evaluating the Usability of an HIV Prevention Artificial Intelligence Chatbot in Malaysia: National Observational Study

Participants who reside outside Malaysia were excluded because this study aimed to create an AI chatbot that is culturally tailored for MSM living in Malaysia. We recruited 334 participants, who generated 393 interactions with the AI chatbot. An interaction was defined as a contact initiated by a user with the chatbot.

Zhao Ni, Sunyoung Oh, Rumana Saifi, Iskandar Azwa, Frederick L Altice

JMIR Hum Factors 2025;12:e70034

Development and Validation of a Large Language Model–Powered Chatbot for Neurosurgery: Mixed Methods Study on Enhancing Perioperative Patient Education

Development and Validation of a Large Language Model–Powered Chatbot for Neurosurgery: Mixed Methods Study on Enhancing Perioperative Patient Education

Comparisons among the 3 chatbot models (Chat GPT, Assistants API, and Qwen) were conducted using one-way ANOVA. For pairwise comparisons between 2 chatbot models (Chat GPT and Assistants API), a paired t test was applied. A 2-sided P The interview transcripts were analyzed using an inductive thematic approach to identify common themes and subthemes related to the participants’ experiences with the Neuro Bot [18].

Chung Man Ho, Shaowei Guan, Prudence Kwan-Lam Mok, Candice HW Lam, Wai Ying Ho, Calvin Hoi-Kwan Mak, Harry Qin, Arkers Kwan Ching Wong, Vivian Hui

J Med Internet Res 2025;27:e74299

Chatbot-Delivered Stage of Change–Tailored Web-Based Intervention to Promote Physical Activity Among Inactive Community-Dwelling People Aged 65 years or More: Protocol for a Randomized Controlled Trial

Chatbot-Delivered Stage of Change–Tailored Web-Based Intervention to Promote Physical Activity Among Inactive Community-Dwelling People Aged 65 years or More: Protocol for a Randomized Controlled Trial

A chatbot will be developed and maintained on the Whats App platform due to its wide popularity among local older adults and a user-friendly interface. The architecture of the chatbot system is shown in Figure 2. Users send information to the Whats App instant messaging server, which then delivers the message to the chatbot. The chatbot system processes and sends a message back to Whats App, where users can view the information.

Xue Liang, Fenghua Sun, Qingpeng Zhang, Yuan Fang, Fuk-yuen Yu, Danhua Ye, Borui Zhang, Qianwen Liao, Phoenix KH Mo, Zixin Wang

JMIR Res Protoc 2025;14:e68796

User and Provider Experiences With Health Education Chatbots: Qualitative Systematic Review

User and Provider Experiences With Health Education Chatbots: Qualitative Systematic Review

Boggiss et al [19] further supported this, noting that nearly all users wanted to customize chatbot interactions. Trust issues, particularly those related to privacy, hinder adoption. Barnett et al [16] expressed concerns about confidentiality, noting uncertainty regarding who has access to chatbot interactions and thus preferring traditional doctor–patient confidentiality. Technical issues such as app freezes and connectivity problems were barriers.

Кyung-Eun (Anna) Choi, Sebastian Fitzek

JMIR Hum Factors 2025;12:e60205

Analysis of the Political Viewpoint of Policy Statements From Professional Medical Organizations Using ChatGPT With GPT-4: Cross-Sectional Study

Analysis of the Political Viewpoint of Policy Statements From Professional Medical Organizations Using ChatGPT With GPT-4: Cross-Sectional Study

Chat GPT is a chatbot designed to understand input presented by users and provide a humanlike text response. We limited our analysis to flagship organizations for medical specialties that are considered core rotations in medical school (pediatrics, surgery, psychiatry, obstetrics and gynecology, internal medicine, and family medicine). This cross-sectional study was performed in accordance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement.

Ben Knudsen, Amr Madkour, Preetam Cholli, Alyson Haslam, Vinay Prasad

JMIR Form Res 2025;9:e66204

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Indeed, creating a hybrid chatbot with both rule-based and LLM components can offer a versatile and streamlined user experience by ensuring that key information is covered in the rule-based components of the chatbot and allowing for the LLM component to support complex, open-ended queries that are not covered in the scripted content.

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848