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Game Design, Effectiveness, and Implementation of Serious Games Promoting Aspects of Mental Health Literacy Among Children and Adolescents: Systematic Review

Game Design, Effectiveness, and Implementation of Serious Games Promoting Aspects of Mental Health Literacy Among Children and Adolescents: Systematic Review

It is well established that mental health problems are common among adolescents [1-3], a situation further exacerbated by the COVID-19 pandemic [4-6]. Almost 50% of psychological disorders develop before the age of 14 years [7]. Current research suggests that—apart from full-syndrome psychiatric disorders—subclinical mental health problems in adolescents are on the rise, which underscores the public health relevance of this topic [8,9].

Michael Zeiler, Sandra Vögl, Ursula Prinz, Nino Werner, Gudrun Wagner, Andreas Karwautz, Natalie Zeller, Lorenz Ackermann, Karin Waldherr

JMIR Ment Health 2025;12:e67418

Integration of a Mental Health App (e-MICHI) Into a Blended Treatment of Depression in Adolescents: Single-Group, Naturalistic Feasibility Trial

Integration of a Mental Health App (e-MICHI) Into a Blended Treatment of Depression in Adolescents: Single-Group, Naturalistic Feasibility Trial

Major depressive disorder (MDD) is a prevalent psychiatric diagnosis among adolescents and the primary cause of inpatient treatment of adolescents in Germany [1,2]. Cognitive behavioral therapy (CBT) is the first-line treatment [3,4]. Digital health interventions (DHIs) could contribute to facilitated access to psychotherapeutic treatment [5]. Adolescents and young adults show the greatest openness and acceptance toward mental e-health interventions [6].

Lena Lincke, Tim Martin-Döring, Andrea Daunke, Antonia Sadkowiak, Daria Alexandra Nolkemper, Nina Sproeber-Kolb, Stefanie Bienioschek, Olaf Reis, Michael Kölch

JMIR Form Res 2025;9:e58427

Short- and Long-Term Effectiveness of Brief Intensive Trauma Treatment for Adolescents With Posttraumatic Stress Disorder and Their Caregivers: Protocol for a Multicenter Randomized Controlled Trial

Short- and Long-Term Effectiveness of Brief Intensive Trauma Treatment for Adolescents With Posttraumatic Stress Disorder and Their Caregivers: Protocol for a Multicenter Randomized Controlled Trial

Adolescents with PTSD have been found to show high rates of psychopathology at the age of 18 years, including 48.8% engaging in self-harm, 20.1% attempting suicide, 54.7% diagnosed with major depressive disorder, 23.8% with generalized anxiety disorder, and 27% with conduct disorder [8]. In addition, subclinical PTSD (s PTSD) in adolescents is often neglected. However, adolescents with s PTSD can experience similar distress as adolescents with full-blown PTSD [9].

Myrna M Westerveld, Malindi van der Mheen, Rik Knipschild, Kim Maijer, Marieke E de Keizer-Altink, Nina Albisser, Marielle J E Hoekstra, Anne Timmermans-Jansen, Rosa Zijp, Anne A Krabbendam, Francisca J A (Bonny) van Steensel, Kees-Jan Kan, Chaim Huyser, Wouter G Staal, Elisabeth M W J Utens, Ramón J L Lindauer

JMIR Res Protoc 2025;14:e66115

Readdressing the Ongoing Challenge of Missing Data in Youth Ecological Momentary Assessment Studies: Meta-Analysis Update

Readdressing the Ongoing Challenge of Missing Data in Youth Ecological Momentary Assessment Studies: Meta-Analysis Update

Future research should more systematically assess how adolescents learn about the scope and intensity of EMA protocols to clarify how perceived burden may deter participation. Until then, researchers can involve youth from the target population as young partners to inquire about their hypothetical acceptance of invitation to enroll across varying numbers of items.

Konstantin Drexl, Vanisha Ralisa, Joëlle Rosselet-Amoussou, Cheng K Wen, Sébastien Urben, Kerstin Jessica Plessen, Jennifer Glaus

J Med Internet Res 2025;27:e65710

Pain Assessment Tools for Infants, Children, and Adolescents With Cancer: Protocol for a Scoping Review

Pain Assessment Tools for Infants, Children, and Adolescents With Cancer: Protocol for a Scoping Review

Annually, an estimated 400,000 children and adolescents aged 0-19 years are diagnosed with all types of cancer [1,2]. Due to advances in medical care, >80% of these children will become long-term survivors in high-income countries, while Palliative care for children refers to the active total care of the child’s body, mind, and spirit, and involves providing support to the family.

Mika Hirata, Noyuri Yamaji, Shotaro Iwamoto, Ayaka Hasegawa, Mitsuru Miyachi, Takashi Yamaguchi, Daisuke Hasegawa, Erika Ota, Nobuyuki Yotani, Japanese Society for Palliative Medicine

JMIR Res Protoc 2025;14:e66614

Mobile Health App for Adolescent Asthma Self-Management: Development and Usability Study of the Pulmonary Education and Knowledge Mobile Asthma Action Plan

Mobile Health App for Adolescent Asthma Self-Management: Development and Usability Study of the Pulmonary Education and Knowledge Mobile Asthma Action Plan

Fedele et al [7] conducted a randomized controlled trial (RCT) to test the feasibility and efficacy of a m Health intervention to enhance caregiver support and asthma self-management in early adolescents, revealing clinically significant improvements in asthma control. Nevertheless, existing m Health asthma apps lack personalization and real-time feedback, and are not tailored for at-risk adolescents.

Xing He, Jiang Bian, Ariel Berlinski, Yi Guo, A Larry Simmons, S Alexandra Marshall, Carolyn J Greene, Rita Hudson Brown, Jessica Turner, Tamara T Perry

JMIR Form Res 2025;9:e64212

Using Music to Promote Hong Kong Young People’s Emotion Regulation and Reduce Their Mood Symptoms and Loneliness: Protocol for a Pilot Randomized Controlled Trial

Using Music to Promote Hong Kong Young People’s Emotion Regulation and Reduce Their Mood Symptoms and Loneliness: Protocol for a Pilot Randomized Controlled Trial

Studies have reported that the prevalence of depression and anxiety among adolescents is approximately 11.3% locally [1]. Loneliness is also widespread among young people in Hong Kong, occurring at a higher rate than that reported for their counterparts in North America [2]. Around 39% of young people in Hong Kong reported feeling lonely—an increase of 55% from 2012 to 2018 [3]. Furthermore, the prevalence of loneliness rose to 47% among adolescents and young adults in 2020 due to the pandemic [4].

Yuan Cao, Yuanxin Shi, Debbie Chi Wing Low, Daniel T L Shek, David H K Shum, Radhika Tanksale, Genevieve Dingle

JMIR Res Protoc 2025;14:e67764

Virtual Reality Respiratory Biofeedback in an Outpatient Pediatric Pain Rehabilitation Program: Mixed Methods Pilot Study

Virtual Reality Respiratory Biofeedback in an Outpatient Pediatric Pain Rehabilitation Program: Mixed Methods Pilot Study

Given the risks associated with these medications and the misuse of prescription opioids among children and adolescents in the United States, it is imperative to advance nonpharmacological interventions for pain [5,6]. Currently, nonpharmacological treatment for chronic pain in adolescents often involves a multidisciplinary approach encompassing pain education, psychological interventions, integrative medicine (mind-body techniques), and physical and occupational therapies [7,8].

Kristin Recker, Julia Silliman, Karolina Gifford, Parth Patel, Lisgelia Santana, Aimee K Hildenbrand, Shreela Palit, Rachel Wasserman

JMIR Rehabil Assist Technol 2025;12:e66352

Adapting Cognitive Behavioral Therapy for Adolescents in Iraq via Mobile Apps: Qualitative Study of Usability and Outcomes

Adapting Cognitive Behavioral Therapy for Adolescents in Iraq via Mobile Apps: Qualitative Study of Usability and Outcomes

Despite the promise of mobile CBT apps, there remains a significant research gap regarding their usability and effectiveness for adolescents [29,30]. Most existing studies focus on adult populations or general app evaluations without considering younger users’ unique needs and preferences [31,32]. Adolescents may have different expectations for user experience, engagement, and motivation when interacting with digital health tools [33,34].

Radhwan Hussein Ibrahim, Marghoob Hussein Yaas, Mariwan Qadir Hamarash, Salwa Hazim Al-Mukhtar, Mohammed Faris Abdulghani, Osama Al Mushhadany

JMIR Pediatr Parent 2025;8:e67137

Amplifying the Voices of Youth for Equity in Wellness and Technology Research: Reflections on the Midwest Youth Wellness Initiative on Technology (MYWIT) Youth Advisory Board

Amplifying the Voices of Youth for Equity in Wellness and Technology Research: Reflections on the Midwest Youth Wellness Initiative on Technology (MYWIT) Youth Advisory Board

The MYWIT holds the goal of working toward health equity by amplifying the voices of adolescents aged 13 to 17 years who self-identify with communities of color around the Midwest region of the United States.

Linnea Laestadius, Fridarose Hamad, Leena Le, Rosemary Buchtel, Celeste Campos-Castillo

JMIR Public Health Surveill 2025;11:e69013