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The tumor microenvironment consists of the stromal background with a variety of cells such as fibroblasts, endothelial cells, and lymphocytes. The tumor-stroma ratio (TSR) is the amount of tumor relative to the amount of stroma in the primary tumor [2-4]. Patients with a high amount of stroma (stroma-high) have a worse prognosis compared to those harboring tumors with a low amount of stroma (stroma-low) in multiple types of cancer [5-13].
JMIR Form Res 2021;5(3):e19408
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Part 2 will involve validation in a prospective cohort of colon cancer stage II-III patients within this multicenter setting. The inclusion is expected to take 3 years, with a 3-year follow-up period.
In the UNITED study, all patients are diagnosed with pathological stage (p-stage) II or p-stage III colon cancer. For e-learning, H&E-stained slides of stage II-III colon cancer patients were selected in a retrospective manner.
JMIR Res Protoc 2019;8(6):e13464
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