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SEARCH Study: Text Messages and Automated Phone Reminders for HPV Vaccination in Uganda: Randomized Controlled Trial

SEARCH Study: Text Messages and Automated Phone Reminders for HPV Vaccination in Uganda: Randomized Controlled Trial

HPV vaccination is the single most important primary preventive measure for HPV [7-9]. A systematic review of HPV vaccine programs across 69 countries over ten years found estimated maximal reductions of 90% for HPV 6/11/16/18 strain infection (ie, the most common cancer-causing strains), 90% for genital warts, and 45% for low-grade and 85% for high-grade cytological cervical abnormalities [10]. HPV also plays an important role in anal, vulvar, penile, and oropharyngeal cancer [4].

Sabrina B Kitaka, Joseph Rujumba, Sarah K Zalwango, Betsy Pfeffer, Lubega Kizza, Juliane P Nattimba, Ashley B Stephens, Nicolette Nabukeera-Barungi, Chelsea S Wynn, Juliet N Babirye, John Mukisa, Ezekiel Mupere, Melissa S Stockwell

JMIR Mhealth Uhealth 2025;13:e63527

Developing an Online Community Advisory Board (CAB) of Parents From Social Media to Co-Design an Human Papillomavirus Vaccine Intervention: Participatory Research Study

Developing an Online Community Advisory Board (CAB) of Parents From Social Media to Co-Design an Human Papillomavirus Vaccine Intervention: Participatory Research Study

We provide a case study, focusing on the development of human papillomavirus (HPV) vaccine messages for parents who use Twitter (rebranded as X in 2023), a microblogging social media platform, to share evidence and findings to support the development of future online CAB creation. Briefly, the HPV vaccine is an important topic for child and adolescent health, and parents are critical stakeholders in deciding whether their child receives the HPV vaccine.

Regan M Murray, Shawn C Chiang, Ann C Klassen, Jennifer A Manganello, Amy E Leader, Wen-Juo Lo, Philip M Massey

JMIR Form Res 2025;9:e65986

Understanding Human Papillomavirus Vaccination Hesitancy in Japan Using Social Media: Content Analysis

Understanding Human Papillomavirus Vaccination Hesitancy in Japan Using Social Media: Content Analysis

While proactive recommendations were reinstated in 2022, HPV vaccine uptake remains low [14-18]. To enhance HPV vaccination uptake in Japan, it is crucial to systematically analyze the trends of vaccine hesitancy. Existing literature reveals varying levels of hesitancy across different populations.

Junyu Liu, Qian Niu, Momoko Nagai-Tanima, Tomoki Aoyama

J Med Internet Res 2025;27:e68881

A Proposed mHealth Intervention to Address Patient Barriers to Colposcopy Attendance: Qualitative Interview Study of Clinic Staff and Patient Perspectives

A Proposed mHealth Intervention to Address Patient Barriers to Colposcopy Attendance: Qualitative Interview Study of Clinic Staff and Patient Perspectives

Over the last few decades, the incidence of invasive cervical cancer in the United States has decreased due to the high uptake of preventive screening and access to human papillomavirus (HPV) vaccination [1-3]. However, there are large and persistent disparities in cervical cancer incidence [4,5] and mortality [6] among minoritized populations [7-11].

Jennifer R Hemler, Rachel B Wagner, Brittany Sullivan, Myneka Macenat, Erin K Tagai, Jazmarie L Vega, Enrique Hernandez, Suzanne M Miller, Kuang-Yi Wen, Charletta A Ayers, Mark H Einstein, Shawna V Hudson, Racquel E Kohler

JMIR Form Res 2025;9:e55043

The Effect of Interventions Based on the Information-Motivation-Behavioral Skills Model on the Human Papillomavirus Vaccination Rate Among 11-13-Year-Old Girls in Central and Western China: Protocol for a Randomized Controlled Trial

The Effect of Interventions Based on the Information-Motivation-Behavioral Skills Model on the Human Papillomavirus Vaccination Rate Among 11-13-Year-Old Girls in Central and Western China: Protocol for a Randomized Controlled Trial

Given the young age of the HPV vaccine target population, this study will focus on HPV vaccine hesitancy among the parents of girls aged 9-14 years. A recent study in mainland China reported that 53.9% of the guardians of secondary school girls aged 12-19 years were HPV vaccine hesitant, mainly because of a lack of knowledge of HPV vaccines and insufficient communication from reliable sources of information [19].

Shu Jing, Yijin Wu, Zhenwei Dai, Shenglan Tang, Xiaoyou Su, Youlin Qiao

JMIR Res Protoc 2024;13:e58873

Electronic Health Interventions and Cervical Cancer Screening: Systematic Review and Meta-Analysis

Electronic Health Interventions and Cervical Cancer Screening: Systematic Review and Meta-Analysis

The primary methods for cervical cancer screening include Papanicolaou smears, HPV DNA testing, cytological examinations, and colposcopy. The WHO advocates HPV DNA testing as the preferred initial screening approach, regardless of whether a triage strategy is used. Women who test positive in the HPV DNA test are recommended to undergo further evaluation through genotyping, colposcopy, visual inspection with acetic acid, or cytological examination [6].

Xiaoxia Liu, Lianzhen Ning, Wenqi Fan, Chanyi Jia, Lina Ge

J Med Internet Res 2024;26:e58066

Development of Promising Interventions to Improve Human Papillomavirus Vaccination in a School-Based Program in Quebec, Canada: Results From a Formative Evaluation Using a Mixed Methods Design

Development of Promising Interventions to Improve Human Papillomavirus Vaccination in a School-Based Program in Quebec, Canada: Results From a Formative Evaluation Using a Mixed Methods Design

Human papillomavirus (HPV) is one of the most commonly transmitted sexual infections [1]. There are over 200 types of HPV, some of which cause cancer (eg, cervical, oropharyngeal, and genital) or genital warts (ie, condylomas) [1]. Most of the oncogenic HPV types can be prevented by vaccination [1]. In Quebec, Canada, HPV vaccination has been offered as part of school-based vaccination programs to boys and girls in grade 4 since 2008.

Maude Dionne, Chantal Sauvageau, Doriane Etienne, Marilou Kiely, Holly Witteman, Eve Dubé

JMIR Form Res 2024;8:e57118

The Role of Scientific Research in Human Papillomavirus Vaccine Discussions on Twitter: Social Network Analysis

The Role of Scientific Research in Human Papillomavirus Vaccine Discussions on Twitter: Social Network Analysis

Almost all cases are attributable to human papillomavirus (HPV), for which an effective vaccine exists [1]. Part of the global strategy to eliminate cervical cancer includes fully vaccinating 90% of girls with the HPV vaccine by the age of 15 years [2]. However, the global HPV immunization coverage currently remains suboptimal [3].

Geneviève Jessiman-Perreault, Jean-Christophe Boucher, So Youn Kim, Nicole Frenette, Abbas Badami, Henry M Smith, Lisa K Allen Scott

JMIR Infodemiology 2024;4:e50551

Projected Time for the Elimination of Cervical Cancer Under Various Intervention Scenarios: Age-Period-Cohort Macrosimulation Study

Projected Time for the Elimination of Cervical Cancer Under Various Intervention Scenarios: Age-Period-Cohort Macrosimulation Study

The incidence rate ratios of cytology-based screening, HPV-based screening, and HPV vaccination were based on the studies of Chen et al [30], Ronco et al [24], and Lei et al [5]. We assume that HPV vaccination administered to 13-year-old girls affords them lifetime effectiveness against cervical cancer [31]. HPV-based screening may have a higher false positive rate, so it is suggested that screening be performed once every 5-10 years [24].

Yi-Chu Chen, Yun-Yuan Chen, Shih-Yung Su, Jing-Rong Jhuang, Chun-Ju Chiang, Ya-Wen Yang, Li-Ju Lin, Chao-Chun Wu, Wen-Chung Lee

JMIR Public Health Surveill 2024;10:e46360

Using Social Listening for Digital Public Health Surveillance of Human Papillomavirus Vaccine Misinformation Online: Exploratory Study

Using Social Listening for Digital Public Health Surveillance of Human Papillomavirus Vaccine Misinformation Online: Exploratory Study

The breadth and depth of COVID-19 misinformation expanded to include all vaccinations, such as human papillomavirus (HPV) vaccination, depressing already suboptimal vaccination uptake in the United States [1,2]. As HPV vaccination is critical to the prevention of various cancers, this could pose significant cancer control challenges in the future [2]. There is an urgent need to address HPV vaccination misinformation to increase HPV vaccination uptake [2].

Dannell Boatman, Abby Starkey, Lori Acciavatti, Zachary Jarrett, Amy Allen, Stephenie Kennedy-Rea

JMIR Infodemiology 2024;4:e54000