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This strategy has been shown to be cost-effective for BRCA1, BRCA2, and Lynch syndrome genes and is endorsed by national and international organizations [5-8]. However, cascade screening uptake in the United States is low, with only 10% to 30% of first- and second-degree relatives receiving genetic testing after hearing about the genetic results of a proband—the initial person identified in a family [3,9,10].
JMIR Cancer 2023;9:e43126
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