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Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

The study has been approved in writing by the Medical Ethics Committee of the Antoni van Leeuwenhoek/Netherlands Cancer Institute (AVL/NKI) to be conducted in all nine University Medical Centers and the Antoni van Leeuwenhoek and has been registered at “CCMO Toetsingonline” from the Dutch Central Committee on Research involving Human Subjects (file number NL63554.031.17) and on Clinical Trials.gov (NCT03835793). Written informed consent will be collected from the participants.

Lara Terra, Maartje J Hooning, Bernadette A M Heemskerk-Gerritsen, Marc van Beurden, Jeanine E Roeters van Lennep, Helena C van Doorn, Joanne A de Hullu, Constantijne Mom, Eleonora B L van Dorst, Marian J E Mourits, Brigitte F M Slangen, Katja N Gaarenstroom, M Carola Zillikens, Tim Leiner, Lizet van der Kolk, Margriet Collee, Marijke Wevers, Margreet G E M Ausems, Klaartje van Engelen, Lieke PV Berger, Christi J van Asperen, Encarna B Gomez-Garcia, Irma van de Beek, Matti A Rookus, Michael Hauptmann, Eveline M Bleiker, Sanne B Schagen, Neil K Aaronson, Angela H E M Maas, Flora E van Leeuwen

JMIR Res Protoc 2021;10(1):e24414

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The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease

The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease

Participating centers are Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam; Catharina Ziekenhuis, Eindhoven; Erasmus Medical Center, Rotterdam; Leiden University Medical Center; Radboudumc, Nijmegen; University Medical Center Groningen; and University Medical Center Utrecht. All patients with histologically proven noninvasive cutaneous VPD visiting or referred to a participating clinic will be asked to participate in this study.

Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu

JMIR Res Protoc 2017;6(9):e178

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