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These comparisons will be based on the LMM coefficients for the time-by-arm interaction at weeks 8 and 26; however, the power calculation is based on 2-sample t tests of differences between the arms in their change scores. Therefore, the power estimate is conservative, that is, in the LMM-based analysis, there will be slightly higher power than the power calculation presented below, with all other assumptions held constant.
JMIR Res Protoc 2023;12:e46281
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