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Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

Long-Term Morbidity and Health After Early Menopause Due to Oophorectomy in Women at Increased Risk of Ovarian Cancer: Protocol for a Nationwide Cross-Sectional Study With Prospective Follow-Up (HARMOny Study)

Blood pressure in mm Hg Pulse frequency per minute Waist (in cm)/hip (in cm) ratio BMI in kg/m2 BMDb values in g/cm2 T and Z scores Presence of osteopenia (defined as T-scores of −1 to −2.5) Presence of osteoporosis (defined as T-scores of ≥−2.5) Vertebral height reduction in percentage Presence of clinical and nonclinical vertebral fractures Bone formation by P1 NPc, mean value in ng/m L Bone resorption by β-CTXd, mean value in pg/m L Level of 25-hydroxyvitamin D in the serum in nmol/L Verbal memory Attention Executive

Lara Terra, Maartje J Hooning, Bernadette A M Heemskerk-Gerritsen, Marc van Beurden, Jeanine E Roeters van Lennep, Helena C van Doorn, Joanne A de Hullu, Constantijne Mom, Eleonora B L van Dorst, Marian J E Mourits, Brigitte F M Slangen, Katja N Gaarenstroom, M Carola Zillikens, Tim Leiner, Lizet van der Kolk, Margriet Collee, Marijke Wevers, Margreet G E M Ausems, Klaartje van Engelen, Lieke PV Berger, Christi J van Asperen, Encarna B Gomez-Garcia, Irma van de Beek, Matti A Rookus, Michael Hauptmann, Eveline M Bleiker, Sanne B Schagen, Neil K Aaronson, Angela H E M Maas, Flora E van Leeuwen

JMIR Res Protoc 2021;10(1):e24414

The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease

The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease

Participating centers are Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam; Catharina Ziekenhuis, Eindhoven; Erasmus Medical Center, Rotterdam; Leiden University Medical Center; Radboudumc, Nijmegen; University Medical Center Groningen; and University Medical Center Utrecht. All patients with histologically proven noninvasive cutaneous VPD visiting or referred to a participating clinic will be asked to participate in this study.

Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu

JMIR Res Protoc 2017;6(9):e178