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The cluster RCT will invite 114 probands to have a total of 104 evaluable subjects (52 for each website). This sample size would allow detecting whether using the adapted Family Gene Toolkit or the comparison website would increase the proportion of informed relatives by 25% with a statistical power of 80%, a significance level of 5%, and a dropout rate of 9.6% (11/114). We estimated the distribution of the proportion of relatives and dropout rates from our previous studies [14,50].
JMIR Res Protoc 2021;10(6):e26264
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