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Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospective, Multicenter Efficacy Study

Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospective, Multicenter Efficacy Study

The 5 principles of the Collaborative Care Model are evidence-based care, measurement-based treatment to target, population health management, accountable care, and team-based care [49]. Practices with integrated mental health clinicians can maximize the impact of digital mental health tools by integrating digital information and interventions into the course of clinical care.

Jussi Seppälä, Eva Grasa, Anna Alonso-Solis, Alexandra Roldan-Bejarano, Marianne Haapea, Matti Isohanni, Jouko Miettunen, Johanna Caro Mendivelso, Cari Almazán, Katya Rubinstein, Asaf Caspi, Zolt Unoka, Kinga Farkas, Elisenda Reixach, Jesus Berdun, Judith Usall, Susana Ochoa, Iluminada Corripio, Erika Jääskeläinen, m-Resist Group

JMIR Hum Factors 2025;12:e67659

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Because of the different modes of administration of these treatments, each group receives both an injection and oral tablets. The study therefore comprises three arms: (1) a “toxin” group treated with an injection of botulinum toxin and placebo oral baclofen; (2) a “baclofen” group treated with oral baclofen and an injection of placebo botulinum toxin; and (3) a double “placebo” group treated with placebo oral baclofen and an injection of placebo botulinum toxin.

Emmeline Montane, Nabila Brihmat, Camille Cormier, Claire Thalamas, Vanessa Rousseau, Gerard Tap, Xavier De Boissezon, Evelyne Castel-Lacanal, Baclotox Group, Philippe Marque

JMIR Res Protoc 2025;14:e62951

Telehealth Initiative to Enhance Primary Care Access in Brazil (UBS+Digital Project): Multicenter Prospective Study

Telehealth Initiative to Enhance Primary Care Access in Brazil (UBS+Digital Project): Multicenter Prospective Study

A collaborative initiative between the HCFMUSP and the UK Government’s Better Health Program developed a Digital PHC proof of concept. This initiative focused on implementing telemedicine service in Santarem, Pará, Brazil, due to the lack of health care services in remote areas. This included teletraining medical and multiprofessional teams to independently operate in telemedicine service, adapting to the specific challenges and realities of the Brazilian context [8].

Celina de Almeida Lamas, Patrícia Gabriela Santana Alves, Luciano Nader de Araújo, Ana Beatriz de Souza Paes, Ana Claudia Cielo, Luciana Maciel de Almeida Lopes, André Longo Araújo de Melo, Thais Yokoyama, Clarice Pagani Savastano, Paula Gobi Scudeller, Carlos Carvalho, Digital Primary Health Unit HCFMUSP Study Group

J Med Internet Res 2025;27:e68434

School-Based Virtual Reality Programming for Obtaining Moderate-Intensity Exercise Among Children With Disabilities: Pre-Post Feasibility Study

School-Based Virtual Reality Programming for Obtaining Moderate-Intensity Exercise Among Children With Disabilities: Pre-Post Feasibility Study

However, to the best of our knowledge, few studies have tested the implementation of a VR HMD exercise program for children with disabilities in high school, particularly using the latest HMD, the Meta Quest 3. The purpose of this 1-year feasibility study was to work with a community engagement group to develop and test the implementation of a VR HMD exergaming program for children with special needs at a high school.

Byron Lai, Ashley Wright, Bailey Hutchinson, Larsen Bright, Raven Young, Drew Davis, Sultan Ali Malik, James H Rimmer, Pelham High Community Engagement Group

JMIR Form Res 2025;9:e65801

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial

For example, an early pilot trial indicated that in-person, group-based meditation was acceptable and generally feasible among officers in the juvenile legal system [10]. However, in-person groups are resource-intensive, face limited instructor availability, and often conflict with the shifting demands of officers’ daily schedules.

Ashley D Kendall, Emily Pela, Danielle Amonica, Erin Jaworski, Brenikki Floyd, The AIM+ Community Advisory Board

JMIR Res Protoc 2025;14:e71867

Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review

Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review

The 10/66 Dementia Research Group study [25] highlights the high cost of dementia for health systems and the negative mental health impacts on women in LMICs, who are often primary caregivers for people with dementia [26]. This underscores the need for further research on dementia diagnosis and care in LMICs and for directing it effectively toward impactful decision-making.

Maria Lazo-Porras, Francisco Jose Tateishi-Serruto, Christopher Butler, María Sofía Cuba-Fuentes, Daniela Rossini-Vilchez, Silvana Perez-Leon, Miriam Lúcar-Flores, J Jaime Miranda, Antonio Bernabe-Ortiz, Francisco Diez-Canseco, Graham Moore, Filipa Landeiro, Maria Kathia Cardenas, Juan Carlos Vera Tudela, Lee White, Rafael A Calvo, William Whiteley, Jemma Hawkins, IMPACT Salud Study Group

JMIR Res Protoc 2025;14:e60296

Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study

Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study

Interviews were audiotaped, transcribed verbatim, and analyzed using the software program NVivo (QSR International) [14]. One researcher (WL) independently analyzed the data, and another researcher (E Mathijsen) reviewed the analysis. Two researchers (WL and E Mathijsen) used several methods to ensure reliability and validity [15-17]. Discrepancies and remarks were discussed until they reached a consensus about data interpretations. Memos were made to track research decisions during analysis.

Jelle Spierings, Gijs Willinge, Marike Kokke, Sjoerd Repping, Wendela de Lange, Thijs Geerdink, Ruben van Veen, Detlef van der Velde, Carel Goslings, Bas Twigt, Collaboration Group

JMIR Hum Factors 2025;12:e53074

Understanding the Engagement and Interaction of Superusers and Regular Users in UK Respiratory Online Health Communities: Deep Learning–Based Sentiment Analysis

Understanding the Engagement and Interaction of Superusers and Regular Users in UK Respiratory Online Health Communities: Deep Learning–Based Sentiment Analysis

This work is part of a research program that will eventually test whether promoting engagement in OHC improves self-management and clinical outcomes [24]. The primary motivation of this study is to investigate the engagement patterns of different user types, particularly superusers and regular users, and how their interactions influence the overall sentiment of posts.

Xiancheng Li, Emanuela Vaghi, Gabriella Pasi, Neil S Coulson, Anna De Simoni, Marco Viviani, AD HOC Group

J Med Internet Res 2025;27:e56038