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Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospective, Multicenter Efficacy Study

Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospective, Multicenter Efficacy Study

In this study, our aim was to evaluate the effects of the m-RESIST solution on the clinical and functional outcomes and the perceived quality of life for those with TRS. To our best knowledge, there are no previous studies which have addressed these issues. This was a prospective, 3-month long, multicenter follow-up study without a control group that was carried out with patients with a diagnosis of TRS between March and November 2017. Blinding was not considered due to the absence of a comparator group.

Jussi Seppälä, Eva Grasa, Anna Alonso-Solis, Alexandra Roldan-Bejarano, Marianne Haapea, Matti Isohanni, Jouko Miettunen, Johanna Caro Mendivelso, Cari Almazán, Katya Rubinstein, Asaf Caspi, Zolt Unoka, Kinga Farkas, Elisenda Reixach, Jesus Berdun, Judith Usall, Susana Ochoa, Iluminada Corripio, Erika Jääskeläinen, m-Resist Group

JMIR Hum Factors 2025;12:e67659

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

This is a multicenter, controlled phase IV, comparative, prospective, randomized, double-blind, double-dummy, superiority trial to compare the toxin and baclofen, and a noninferiority trial to compare the toxin and the placebo. Because of the different modes of administration of these treatments, each group receives both an injection and oral tablets.

Emmeline Montane, Nabila Brihmat, Camille Cormier, Claire Thalamas, Vanessa Rousseau, Gerard Tap, Xavier De Boissezon, Evelyne Castel-Lacanal, Baclotox Group, Philippe Marque

JMIR Res Protoc 2025;14:e62951

Correction: Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study

Correction: Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study

In “Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study” (JMIR Hum Factors 2025;12:e53074) the authors noted one error. The ninth author’s name previously appeared as: Carel Goslings This has been changed to J Carel Goslings The correction will appear in the online version of the paper on the JMIR Publications website, together with the publication of this correction notice.

Jelle Spierings, Gijs Willinge, Marike Kokke, Sjoerd Repping, Wendela de Lange, Thijs Geerdink, Ruben van Veen, Detlef van der Velde, J Carel Goslings, Bas Twigt, Collaboration Group

JMIR Hum Factors 2025;12:e75812

Telehealth Initiative to Enhance Primary Care Access in Brazil (UBS+Digital Project): Multicenter Prospective Study

Telehealth Initiative to Enhance Primary Care Access in Brazil (UBS+Digital Project): Multicenter Prospective Study

The digital health initiatives of the HCFMUSP in PHC began in 2021, driven by the need to address persistent challenges in this health care sector. A collaborative initiative between the HCFMUSP and the UK Government’s Better Health Program developed a Digital PHC proof of concept. This initiative focused on implementing telemedicine service in Santarem, Pará, Brazil, due to the lack of health care services in remote areas.

Celina de Almeida Lamas, Patrícia Gabriela Santana Alves, Luciano Nader de Araújo, Ana Beatriz de Souza Paes, Ana Claudia Cielo, Luciana Maciel de Almeida Lopes, André Longo Araújo de Melo, Thais Yokoyama, Clarice Pagani Savastano, Paula Gobi Scudeller, Carlos Carvalho, Digital Primary Health Unit HCFMUSP Study Group

J Med Internet Res 2025;27:e68434

School-Based Virtual Reality Programming for Obtaining Moderate-Intensity Exercise Among Children With Disabilities: Pre-Post Feasibility Study

School-Based Virtual Reality Programming for Obtaining Moderate-Intensity Exercise Among Children With Disabilities: Pre-Post Feasibility Study

One trial is currently testing the preliminary efficacy of VR HMD exercise training on cardiometabolic health in children with cerebral palsy [20]. However, to the best of our knowledge, few studies have tested the implementation of a VR HMD exercise program for children with disabilities in high school, particularly using the latest HMD, the Meta Quest 3.

Byron Lai, Ashley Wright, Bailey Hutchinson, Larsen Bright, Raven Young, Drew Davis, Sultan Ali Malik, James H Rimmer, Pelham High Community Engagement Group

JMIR Form Res 2025;9:e65801

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial

Moreover, many professionals who work with young people in the legal system express interest in meditation practice [10]. Yet research in this area is sparse, and the scalability of existing efforts has been limited. For example, an early pilot trial indicated that in-person, group-based meditation was acceptable and generally feasible among officers in the juvenile legal system [10].

Ashley D Kendall, Emily Pela, Danielle Amonica, Erin Jaworski, Brenikki Floyd, The AIM+ Community Advisory Board

JMIR Res Protoc 2025;14:e71867

Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study

Artificial Intelligence-Driven Biological Age Prediction Model Using Comprehensive Health Checkup Data: Development and Validation Study

Figure S3 in Multimedia Appendix 1 shows the distribution of gender in the training and test sets as well as the chronological age group distribution in the training and test sets. The models were trained using 27 clinical variables on the full training dataset (80% of the super-control cohort), then predicted on the test set (20%). For generalizability, 5-fold cross-validation with 10 iterative experiments were performed. The model was replicated using the Ko GES HEXA data of 11,968 super-controls.

Chang-Uk Jeong, Jacob S Leiby, Dokyoon Kim, Eun Kyung Choe

JMIR Aging 2025;8:e64473

Bridging Data Gaps in Emergency Care: The NIGHTINGALE Project and the Future of AI in Mass Casualty Management

Bridging Data Gaps in Emergency Care: The NIGHTINGALE Project and the Future of AI in Mass Casualty Management

Of note, even when continuous monitoring occurs in the prehospital environment (eg, in mobile intensive care units), the data are typically not recorded or stored, as they are deemed unnecessary for immediate treatment decisions. The absence of such data, curated accordingly, hinders the ability to create accurate models and limits the potential for AI to improve emergency responses and outcomes.

The NIGHTINGALE Consortium, Marta Caviglia

J Med Internet Res 2025;27:e67318

Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review

Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review

Notably, the 2023 Pan American Health Organization report [25] indicates that only Chile has a national dementia plan, with underreporting in LMICs potentially reaching 90%. The 10/66 Dementia Research Group study [25] highlights the high cost of dementia for health systems and the negative mental health impacts on women in LMICs, who are often primary caregivers for people with dementia [26].

Maria Lazo-Porras, Francisco Jose Tateishi-Serruto, Christopher Butler, María Sofía Cuba-Fuentes, Daniela Rossini-Vilchez, Silvana Perez-Leon, Miriam Lúcar-Flores, J Jaime Miranda, Antonio Bernabe-Ortiz, Francisco Diez-Canseco, Graham Moore, Filipa Landeiro, Maria Kathia Cardenas, Juan Carlos Vera Tudela, Lee White, Rafael A Calvo, William Whiteley, Jemma Hawkins, IMPACT Salud Study Group

JMIR Res Protoc 2025;14:e60296

Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study

Patient Experiences With a Mobile Self-Care Solution for Low-Complex Orthopedic Injuries: Mixed Methods Study

Additionally, the less rigid nature of the brace resulted in increased skin friction, causing a superficial ulcer in 1 patient in the qualitative data. I really like the brace because it allowed me to move. So, I was not stuck with a bulky cast on my leg, but rather, I had a lot of flexibility. I could actually determine what I wanted to do or not. So, I found that very enjoyable. The brace was sometimes the reason I went over my limit. I could move more and was in the process of moving to a new home.

Jelle Spierings, Gijs Willinge, Marike Kokke, Sjoerd Repping, Wendela de Lange, Thijs Geerdink, Ruben van Veen, Detlef van der Velde, Carel Goslings, Bas Twigt, Collaboration Group

JMIR Hum Factors 2025;12:e53074