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Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study

Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study

Overview of unstructured data processing for a single timestep. CUIs are extracted from clinical notes by c TAKES and assembled into a usable data structure that maps encounter ID to a list of CUIs associated with the timestep. A table of CUI-associated data is created, independent of patient data, containing preferred text, ICD codes, Sap BERT embedding, and cluster information.

Charles A Kotula, Jennie Martin, Kyle A Carey, Dana P Edelson, Dmitriy Dligach, Anoop Mayampurath, Majid Afshar, Matthew M Churpek

J Med Internet Res 2025;27:e75340

Relationship of Hair Cortisol Concentration With Perceived and Somatic Stress Indices: Cross-Sectional Pilot Study

Relationship of Hair Cortisol Concentration With Perceived and Somatic Stress Indices: Cross-Sectional Pilot Study

Since cortisol is incorporated into growing hair, hair is emerging as a novel matrix for measuring retrospective cortisol secretion over months [9,11,12]. Each 1 cm hair segment, beginning from the proximal end, approximates a month’s cortisol production.

Sharon H Bergquist, Danyang Wang, Brad Pearce, Alicia K Smith, Allison Hankus, David L Roberts, Miranda A Moore

JMIR Form Res 2025;9:e63811

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Nivel-PCD: All insurance claims codes as recorded by the GP are received, however, when a dataset has been requested by the researcher, the codes are filtered by the data processor to include a selection of codes relevant to the study (in agreement with the researchers), on a database zone level. Contacts Defined as moments of contact between a GP and a patient. Based on unique dates on which an insurance claim code was recorded by the GP, that is, the maximum number of contacts per patient per day is 1.

Melissa H J van Essen, Robin Twickler, Yvette M Weesie, Ilgin G Arslan, Feikje Groenhof, Lilian L Peters, Isabelle Bos, Robert A Verheij

J Med Internet Res 2025;27:e64628

Research Electronic Data Capture (REDCap) for Population-Based Data Collection in Low- and Middle-Income Countries: Opportunities, Challenges, and Solutions

Research Electronic Data Capture (REDCap) for Population-Based Data Collection in Low- and Middle-Income Countries: Opportunities, Challenges, and Solutions

The survey was a cross-sectional household survey forming the baseline of a cluster-randomized trial. Data collection was completed district by district: Nghia Hung in April 2022, Hai Hau in April 2023, and Xuan Truong in May 2023. A list of communes with active Community Health Centers was compiled by province-level officials. A total of 64 communes meeting eligibility criteria were chosen for the study. In each community, we randomly sampled approximately 195 people for each survey.

Ha Thanh Le, Dung Viet Tien Vu, Thi Ngoc Anh Nguyen, Hang Tran Thi, Tan Viet Nguyen, Thao Phuong Tran, Aria Kekalih, Samita Rijal, Dewi Friska, Raph L. Hamers, Abhilasha Karkey, Mary Chambers, Jennifer Ilo Van Nuil, SPEAR and CoAct Team, Sonia Lewycka

J Med Internet Res 2025;27:e65377

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study

Addressing care partner needs is a pressing health, economic, and social imperative. There is a growing literature on web-based peer support networks for care partners of people with serious illness, and such networks typically contain a platform to exchange information and provide peer support [5].

Aricca D Van Citters, Megan M Holthoff, Colleen Young, Sarah M Eck, Amelia M Cullinan, Stephanie Carney, Elizabeth A O'Donnell, Joel R King, Malavika Govindan, David Gustafson, Stephanie C Tomlin, Anne B Holmes, Ann D Bradley, Brant J Oliver, Matthew M Wilson, Eugene C Nelson, Amber E Barnato, Kathryn B Kirkland

JMIR Form Res 2025;9:e70206

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Exclusion criteria for individuals with MDD included a severe neurodevelopmental disorder or other impairment that impacts the participant’s ability to provide the required information for the study (eg, symptom reports), a substance or medication-induced affective disorder, an affective disorder secondary to a medical condition, and a current Axis I psychotic or bipolar disorder.

Jimena Unzueta Saavedra, Emma A Deaso, Margot Austin, Laura Cadavid, Rachel Kraff, Emma E M Knowles

JMIR Form Res 2025;9:e66187

Addendum to "Harnessing ChatGPT for Thematic Analysis: Are We Ready?"

Addendum to "Harnessing ChatGPT for Thematic Analysis: Are We Ready?"

Since our publication, Open AI released a new series of reasoning models–the o-series–with the o1-preview launched in September 2024 and the o3 model released in April 2025.

Stephanie C C van der Lubbe, V Vien Lee, Lay Hoon Goh, Jose Maria Valderas

J Med Internet Res 2025;27:e68963

Exploring the Barriers to and Facilitators of Using Virtual Reality Relaxation for Patients With Psychiatric Problems: Qualitative Focus Group Study

Exploring the Barriers to and Facilitators of Using Virtual Reality Relaxation for Patients With Psychiatric Problems: Qualitative Focus Group Study

The participants received a financial reimbursement of €40 (US $45.35) for the time invested. A total of 4 focus groups were conducted with 19 participants between May 2021 and July 2021.

Lisanne M Robbemond, JWH Mathijs Nijland, Manna Alma, Wim Veling, Catheleine MG van Driel

J Med Internet Res 2025;27:e65308

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbots are a highly accessible and scalable platform that allows for simulated conversations. Accessible via the web through a hyperlink or downloadable app, chatbots can be used on a smartphone, tablet, or computer. The use of chatbots has also been shown to improve access to services and support health equity by providing personalized health education, being available in multiple languages, and offering continuous access to information [11-15].

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

However, CDD has a distinct genetic cause and symptom profile, as severe developmental delay is exhibited from birth and seizure onset occurs earlier, and it was thus established as a separate clinical condition in 2013 [3-5]. CDD is caused by pathogenic variants in the X-linked gene CDKL5, which plays a key role in normal brain development and function [6].

Sam Amin, Carol-Anne Partridge, Helen Leonard, Jenny Downs, Helen Allvin, Valentine Ficara, Emilie Pain, Minna A Korolainen

JMIR Form Res 2025;9:e72489