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Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

This can work well when quick responses are needed (for example, a travel itinerary), but could be potentially problematic when used in the context of mental health. For example, this approach may replace guided self-discovery by a trained therapist with less relevant advice and answers extracted from the archives of the internet. At the core of a successful outcome in therapy is the relationship between a client and a therapist [5].

Timothy R Campellone, Megan Flom, Robert M Montgomery, Lauren Bullard, Maddison C Pirner, Aaron Pavez, Michelle Morales, Devin Harper, Catherine Oddy, Tom O'Connor, Jade Daniels, Stephanie Eaneff, Valerie L Forman-Hoffman, Casey Sackett, Alison Darcy

J Med Internet Res 2025;27:e67365

Developing a Core Outcome Set for Pediatric and Adult Acute and Chronic Pain Extended Reality Trials: Delphi Consensus-Building Process

Developing a Core Outcome Set for Pediatric and Adult Acute and Chronic Pain Extended Reality Trials: Delphi Consensus-Building Process

Finally, they were asked to rate the perceived importance of a variety of possible domains and constructs representing potential outcomes and mechanisms of XR interventions for pain using a numeric scale from 0 to 10 (0=not at all important; 10=extremely important). Surveys were administered through a REDCap (Research Electronic Data Capture; Vanderbilt University) interface hosted by the Boston Children’s Hospital.

Courtney W Hess, Deirdre E Logan, Brittany N Rosenbloom, Giulia Mesaroli, Laura E Simons, Carley Ouellette, Cynthia Nguyen, Fahad Alam, Jennifer N Stinson

J Med Internet Res 2025;27:e58947

Effect of a Tailored eHealth Physical Activity Intervention on Physical Activity and Depression During Postpartum: Randomized Controlled Trial (The Postpartum Wellness Study)

Effect of a Tailored eHealth Physical Activity Intervention on Physical Activity and Depression During Postpartum: Randomized Controlled Trial (The Postpartum Wellness Study)

The website also included a page to set a weekly PA goal and visually tracked (via a graph) the number of videos watched per week. Participants randomized to the intervention group received individual login information for the Mom Zing website via email and up to 6 reminders (text and email per each participant’s preference) to log into the Mom Zing website (73% text and 27% email).

Sylvia E Badon, Nina Oberman, Maya Ramsey, Charles P Quesenberry, Elaine Kurtovich, Lizeth Gomez Chavez, Susan D Brown, Cheryl L Albright, Mibhali Bhalala, Lyndsay A Avalos

JMIR Ment Health 2025;12:e64507

Evaluation of the Aspects of Digital Interventions That Successfully Support Weight Loss: Systematic Review With Component Network Meta-Analysis

Evaluation of the Aspects of Digital Interventions That Successfully Support Weight Loss: Systematic Review With Component Network Meta-Analysis

This could refer to a single digital component or a combination of digital approaches. No face-to-face delivery of content occurred, but this definition allows for a baseline in-person contact to set-up digital components or in-person assessment visits. Digitally led: Trial arm received content primarily via digital means.

Michael Nunns, Samantha Febrey, Rebecca Abbott, Jill Buckland, Rebecca Whear, Liz Shaw, Alison Bethel, Kate Boddy, Jo Thompson Coon, G.J. Melendez-Torres

J Med Internet Res 2025;27:e65443

Auxiliary Teaching and Student Evaluation Methods Based on Facial Expression Recognition in Medical Education

Auxiliary Teaching and Student Evaluation Methods Based on Facial Expression Recognition in Medical Education

Facial expression recognition technology can capture students’ emotional reactions, providing teachers with a more comprehensive evaluation basis, thereby more accurately assessing students’ comprehensive qualities and potential. In addition, traditional medical education often adopts a teacher-led teaching mode in teaching methods, lacking student participation and interaction.

Xueling Zhu, Roben A Juanatas

JMIR Hum Factors 2025;12:e72838

Statistical Relationship Between Wastewater Data and Case Notifications for COVID-19 Surveillance in the United States From 2020 to 2023: Bayesian Hierarchical Modeling Approach

Statistical Relationship Between Wastewater Data and Case Notifications for COVID-19 Surveillance in the United States From 2020 to 2023: Bayesian Hierarchical Modeling Approach

We restricted the analysis to counties with a minimum of 50 weeks of available wastewater data during the study period, which resulted in 107 counties being included, covering a range of geographic areas within the United States, and with periods of data incompleteness for the majority of counties. We assessed the correlation between wastewater metrics and case totals with different time lags (0 wk, 1 wk, 2 wk, etc), and found that a 0 week time lag has the highest correlation.

Masahiko Haraguchi, Fayette Klaassen, Ted Cohen, Joshua A Salomon, Nicolas A Menzies

JMIR Public Health Surveill 2025;11:e68213

The American Transformative HIV Study: Protocol for a US National Cohort of Sexual and Gender Minority Individuals With HIV

The American Transformative HIV Study: Protocol for a US National Cohort of Sexual and Gender Minority Individuals With HIV

Key questions answered by including these participants will include identifying psychosocial and demographic factors associated with a timeline to sample return (for those who return a sample at a future wave) as well as how these factors differentiate those who do not return a sample going forward. We estimated pre-enrollment HIV incidence using baseline data on HIV serostatus and HIV testing history prior to joining the study.

Christian Grov, Alexa B D'Angelo, Chloe Mirzayi, Michelle Dearolf, Elena Hoeppner, Yan Guo, Nicole Richards, Rifa Ehsan, Sarah Kulkarni, Denis Nash, Viraj V Patel, Dustin T Duncan, Meredith Ray, Tyler Bartholomew, Jennifer Manuzak, Jennifer Manuel, Kathryn McCollister, Drew Westmoreland, Adam W Carrico

JMIR Public Health Surveill 2025;11:e66921

Application of Machine Learning and Emerging Health Technologies in the Uptake of HIV Testing: Bibliometric Analysis of Studies Published From 2000 to 2024

Application of Machine Learning and Emerging Health Technologies in the Uptake of HIV Testing: Bibliometric Analysis of Studies Published From 2000 to 2024

The VOSviewer software (version 1.6.20) provides a visualized and comprehensive understanding of the relationships between different networks within the dataset [20]. Normalization was applied at full counting for co-citation, co-occurrence, and international collaboration analyses. A maximum of 25 countries per document and a minimum of 5 documents per country were established as eligibility criteria, resulting in 53 eligible countries, of which 13 met the collaboration threshold.

Musa Jaiteh, Edith Phalane, Yegnanew A Shiferaw, Lateef Babatunde Amusa, Hossana Twinomurinzi, Refilwe Nancy Phaswana-Mafuya

Interact J Med Res 2025;14:e64829

A Just-in-Time Adaptive Intervention (Shift) to Manage Problem Anger After Trauma: Co-Design and Development Study

A Just-in-Time Adaptive Intervention (Shift) to Manage Problem Anger After Trauma: Co-Design and Development Study

A JITAI includes 6 key elements, namely a distal outcome, proximal outcomes, decision points, intervention options, tailoring variables, and decision rules. While research has established that digital mental health tools for problem anger are feasible, much remains unknown about how to design a JITAI for this population, and more empirical work including data-driven approaches to designing JITAI is needed [14,17].

Olivia Metcalf, David Forbes, Lauren M Henry, Tianchen Qian, Tracey Varker, Melissa A Brotman, Sean Cowlishaw, Karen E Lamb, Meaghan L O'Donnell

JMIR Hum Factors 2025;12:e62960