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Skip search results from other journals and go to results- 1265 Journal of Medical Internet Research
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Notably, the main barriers occur well before a clinical trial is even offered to a patient [1]. That is, patients are not the main cause of low participation rates. The upstream nonpatient barriers can be structural (eg, access to a trial), clinical (eg, eligibility criteria) or doctor related (eg, offering a clinical trial) [1]. Indeed, when clinical trials are offered to patients with cancer, many (55%) agree to participate [1].
J Particip Med 2025;17:e72015
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An initial CLIQ framework was developed through a systematic review and qualitative synthesis of existing information quality frameworks for DHTs [11]. A CLIQ assessment questionnaire was then developed based on the CLIQ framework and further evidence from literature [21]. The questionnaire offers a pragmatic approach to assessing clinical information in DHTs based on relatable clinical scenarios.
JMIR Med Inform 2025;13:e58125
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Generative artificial intelligence (Gen AI) systems, developed by organizations such as Anthropic (Claude), Open AI (Chat GPT), Google (Gemini), Microsoft (Copilot), and Meta (Llama), represent a significant technological shift and are rapidly being adopted in diverse sectors globally at an unprecedented speed [1]. Health care represents a domain where Gen AI holds considerable transformative potential.
J Med Internet Res 2025;27:e73918
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Suicide is a common cause of premature mortality among people living with schizophrenia [3,4] and a recent systematic review has reported a point prevalence of nearly 30% of SIs in people with schizophrenia [5].
Most of the empirical research on the risks of suicidality includes cross-sectional or retrospective studies that distinguish the characteristics between people who experience SIs or suicidal behavior, and those who do not [6-8].
JMIR Form Res 2025;9:e67745
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Due to potential limited computing infrastructures available to generate real-time predictions based on ML algorithms (eg, random forest) in some clinical settings, we also implemented a simplified version of the prediction approach described above in which we restricted the library of candidate predictors to a main-term logistic regression using training data pooled across all 8 quarters. This is equivalent to a classical discrete-time survival model with a logit link function [36].
JMIR Diabetes 2025;10:e60141
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By using a 95% confidence level and a 5% margin error, the sample should have been 385. Accounting for potential nonresponse, our target sample size in phase II was 400 participants.
We recruited participants through the local study partners (see the Study Team and Cooperation section).
We used a multistage approach to select primary health care facilities in the country.
JMIR Res Protoc 2025;14:e62929
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In a crisis, despite intense pressure, complexity, and uncertainty, leaders must be decisive, obtain and allocate stretched resources, and communicate clearly with employees, often under a spotlight [30-32].
JMIR Res Protoc 2025;14:e66402
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Tools were assigned a rating of ✓ if responsiveness of the digital tool to cognitive change over time was reported.
Clinical meaningfulness is not considered a psychometric property but, rather, an important tool characteristic for interpretability of a (change in) score [29]. Clinical meaningfulness refers to a score (or its change) that can be interpreted as clinically relevant such that a qualitative meaning is assigned to the quantitative score [16,29].
J Med Internet Res 2025;27:e65297
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Patients in underdeveloped health care systems are not consistently diagnosed or treated because of a lack of information, infrastructure, resources, shortage of equipment, a lack of diagnostic accuracy, a lack of health education, and budgetary constraints, which prevents them from undergoing periodical medical examinations [9,10].
JMIR Public Health Surveill 2025;11:e72233
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For instance, some participants favored evidence-based disease-related resources because they helped them learn about unfamiliar topics and clinically reason through possibilities while generating differential diagnoses for a medical case:
It’s a good start for me to go to something like Up To Date for a disease state that I’m not familiar with, just because it does give you a general recommendation, but it also ties in a lot of the most recent guidelines of literature.
JMIR Med Inform 2025;13:e60191
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