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Although the pharmacotherapies naltrexone and acamprosate are efficacious for AUD, a recent meta-analysis indicates small effects (Hedges g=0.21) compared to placebo [3]. High rates of return to hazardous alcohol consumption after treatment (approximately 60%) [4] necessitate the development of more efficacious primary or adjunct interventions.
Among veterans with mild traumatic brain injury (m TBI), AUD rates are as high as 35% [5,6].
JMIR Res Protoc 2025;14:e64909
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