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Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Moreover, the burden and cost of administering a full cognitive assessment would likely make such an approach unrealistic. One possible solution to this issue is the development of a digital platform with automated administration/scoring, designed for remote data collection—eliminating the need for participants to visit a clinic [18].

John Frederick Dyer, Florentine Marie Barbey, Ayan Ghoshal, Ann Marie Hake, Bryan J Hansen, Md Nurul Islam, Judith Jaeger, Rouba Kozak, Hugh Marston, Mark Moss, Viet Nguyen, Rebecca Louise Quinn, Leslie A Shinobu, Elizabeth Tunbridge, Brian Murphy, Niamh Kennedy

J Med Internet Res 2025;27:e55469

The Influence of Medical Culture and Key Factors on Mobile App Usage Frequency and Perceived Effectiveness in Physical Therapy: Cross-Sectional Study

The Influence of Medical Culture and Key Factors on Mobile App Usage Frequency and Perceived Effectiveness in Physical Therapy: Cross-Sectional Study

Conversely, a rigid or traditional medical culture can act as a barrier to the usage of new technologies and methods [4]. The role of medical culture extends beyond the attitudes of individual professionals, influencing how teams function and how institutions respond to emerging challenges in health care [5].

Khalid A Alahmari, Ravi Shankar Reddy

J Med Internet Res 2025;27:e68406

Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study

Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study

Overview of unstructured data processing for a single timestep. CUIs are extracted from clinical notes by c TAKES and assembled into a usable data structure that maps encounter ID to a list of CUIs associated with the timestep. A table of CUI-associated data is created, independent of patient data, containing preferred text, ICD codes, Sap BERT embedding, and cluster information.

Charles A Kotula, Jennie Martin, Kyle A Carey, Dana P Edelson, Dmitriy Dligach, Anoop Mayampurath, Majid Afshar, Matthew M Churpek

J Med Internet Res 2025;27:e75340

Relationship of Hair Cortisol Concentration With Perceived and Somatic Stress Indices: Cross-Sectional Pilot Study

Relationship of Hair Cortisol Concentration With Perceived and Somatic Stress Indices: Cross-Sectional Pilot Study

Since cortisol is incorporated into growing hair, hair is emerging as a novel matrix for measuring retrospective cortisol secretion over months [9,11,12]. Each 1 cm hair segment, beginning from the proximal end, approximates a month’s cortisol production.

Sharon H Bergquist, Danyang Wang, Brad Pearce, Alicia K Smith, Allison Hankus, David L Roberts, Miranda A Moore

JMIR Form Res 2025;9:e63811

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Nivel-PCD: All insurance claims codes as recorded by the GP are received, however, when a dataset has been requested by the researcher, the codes are filtered by the data processor to include a selection of codes relevant to the study (in agreement with the researchers), on a database zone level. Contacts Defined as moments of contact between a GP and a patient. Based on unique dates on which an insurance claim code was recorded by the GP, that is, the maximum number of contacts per patient per day is 1.

Melissa H J van Essen, Robin Twickler, Yvette M Weesie, Ilgin G Arslan, Feikje Groenhof, Lilian L Peters, Isabelle Bos, Robert A Verheij

J Med Internet Res 2025;27:e64628

Evaluating the User Experience and Usability of Game-Based Cognitive Assessments for Older People: Systematic Review

Evaluating the User Experience and Usability of Game-Based Cognitive Assessments for Older People: Systematic Review

The first is “gamification,” the process of building game-like features onto a cognitive task. This includes adding points, time limits, or appealing graphics to the foundational design of a traditional task. The second is to create or use an “actual” game, where the entire environment has been purposefully designed to be a game.

Rhys Mantell, Ye In Jane Hwang, Matthew Dark, Kylie Radford, Michael Kasumovic, Lauren Monds, Peter W Schofield, Tony Butler, Adrienne Withall

JMIR Aging 2025;8:e65252

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study

Addressing care partner needs is a pressing health, economic, and social imperative. There is a growing literature on web-based peer support networks for care partners of people with serious illness, and such networks typically contain a platform to exchange information and provide peer support [5].

Aricca D Van Citters, Megan M Holthoff, Colleen Young, Sarah M Eck, Amelia M Cullinan, Stephanie Carney, Elizabeth A O'Donnell, Joel R King, Malavika Govindan, David Gustafson, Stephanie C Tomlin, Anne B Holmes, Ann D Bradley, Brant J Oliver, Matthew M Wilson, Eugene C Nelson, Amber E Barnato, Kathryn B Kirkland

JMIR Form Res 2025;9:e70206

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Exclusion criteria for individuals with MDD included a severe neurodevelopmental disorder or other impairment that impacts the participant’s ability to provide the required information for the study (eg, symptom reports), a substance or medication-induced affective disorder, an affective disorder secondary to a medical condition, and a current Axis I psychotic or bipolar disorder.

Jimena Unzueta Saavedra, Emma A Deaso, Margot Austin, Laura Cadavid, Rachel Kraff, Emma E M Knowles

JMIR Form Res 2025;9:e66187

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbots are a highly accessible and scalable platform that allows for simulated conversations. Accessible via the web through a hyperlink or downloadable app, chatbots can be used on a smartphone, tablet, or computer. The use of chatbots has also been shown to improve access to services and support health equity by providing personalized health education, being available in multiple languages, and offering continuous access to information [11-15].

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

However, CDD has a distinct genetic cause and symptom profile, as severe developmental delay is exhibited from birth and seizure onset occurs earlier, and it was thus established as a separate clinical condition in 2013 [3-5]. CDD is caused by pathogenic variants in the X-linked gene CDKL5, which plays a key role in normal brain development and function [6].

Sam Amin, Carol-Anne Partridge, Helen Leonard, Jenny Downs, Helen Allvin, Valentine Ficara, Emilie Pain, Minna A Korolainen

JMIR Form Res 2025;9:e72489