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The Systematic Removal of Participants Post-Randomization Can Lead to Alternate Explanations of the Results

The Systematic Removal of Participants Post-Randomization Can Lead to Alternate Explanations of the Results

This can introduce a potential confound or alternative explanation of the results. The recently published study by Rooke et al [1] removed participants from the analysis who reported other treatment use during the study (n=5).

John A Cunningham

J Med Internet Res 2013;15(6):e128


Claiming Positive Results From Negative Trials: A Cause for Concern in Randomized Controlled Trial Research

Claiming Positive Results From Negative Trials: A Cause for Concern in Randomized Controlled Trial Research

This is especially a challenge when the RCT involves the comparison of two or more interventions rather than an intervention compared to some form of no-intervention control group.

John A Cunningham

J Med Internet Res 2013;15(8):e179