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Currently submitted to: JMIR Cancer

Date Submitted: Nov 27, 2019
Open Peer Review Period: Nov 27, 2019 - Jan 22, 2020
(currently open for review)

Clinical, biochemical and radiological profile of bone metstases along with pain score and quality of life in solid malignancies at a tertiary care hospital in North India: Two year prospective study

  • HakimIrfan Showkat; 
  • G M Bhat; 
  • Arif Sarmast; 
  • Basharat Jan; 
  • Nazir Khan; 
  • Irfan Robbani; 
  • Sheikh Aijaz Azeez; 

ABSTRACT

Background:

AIM:To study the clinical, biochemical , radioligical profile of bone metastases along with distribution of skeletal metastases with management strategies and effect on quality of life

Objective:

AIM:To study the clinical, biochemical , radioligical profile of bone metastases along with distribution of skeletal metastases with management strategies and effect on quality of life

Methods:

MATERIAL & METHODS:This is a Two year prospective study from August 2013 to August 2015.Patients with a proven malignancy with bone scan positive metastatic skeletal lesions were taken and the clinical, biochemical & radiological manifestations of were analysed.Pain score by visual analogue score (VAS) both pre-treatment and post treatment were noted. Quality of life was noted at the baseline using European Organization for Research and Treatment of Cancer Quality of Life Group (EORTC) -Q30 questionnaire.

Results:

It was observed that majority of patients were males (58.8%).Bone metastases was most common in lung malignancy (30.4%) followed by carcinoma prostate (19.2%). Carcinoma breast was the third most common malignancy (18.8%) and most common malignancy with bone metastases in females. Pain was the most common presentation (83.6%).Alkaline phosphatase was raised in 80 % of cases & lactate Dehydrogenase was high in 92.4%.Osteolytic lesions were seen in 56.4% cases, osteosclerotic/osteoblastic in 32.4% while 11.2% cases had mixed lesions. Target X-ray imaging was positive in 46.8%, computed tomography (CT) scan 86.6%,magnetic resonance imaging (MRI) 81.4%,positron emission tomography (PET/CT) scan 93.3%. Non-Opiod analgesics were commonly used in 83.2% cases followed by Bisphosphonates in 82% .Pain score as per VAS scale improved significantly in all cases of bone metastases post intervention.Quality of life as per EORTC-30 questionnaire was impaired significantly in all cases with 86% cases having moderate to severe impairment.

Conclusions:

It was observed that majority of patients were males (58.8%).Bone metastases was most common in lung malignancy (30.4%) followed by carcinoma prostate (19.2%). Carcinoma breast was the third most common malignancy (18.8%) and most common malignancy with bone metastases in females. Pain was the most common presentation (83.6%).Alkaline phosphatase was raised in 80 % of cases & lactate Dehydrogenase was high in 92.4%.Osteolytic lesions were seen in 56.4% cases, osteosclerotic/osteoblastic in 32.4% while 11.2% cases had mixed lesions. Target X-ray imaging was positive in 46.8%, computed tomography (CT) scan 86.6%,magnetic resonance imaging (MRI) 81.4%,positron emission tomography (PET/CT) scan 93.3%. Non-Opiod analgesics were commonly used in 83.2% cases followed by Bisphosphonates in 82% .Pain score as per VAS scale improved significantly in all cases of bone metastases post intervention.Quality of life as per EORTC-30 questionnaire was impaired significantly in all cases with 86% cases having moderate to severe impairment.


 Citation

Please cite as:

Showkat H, Bhat GM, Sarmast A, Jan B, Khan N, Robbani I, Azeez SA

Clinical, biochemical and radiological profile of bone metstases along with pain score and quality of life in solid malignancies at a tertiary care hospital in North India: Two year prospective study

JMIR Preprints. 27/11/2019:17228

DOI: 10.2196/preprints.17228

URL: https://preprints.jmir.org/preprint/17228


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