TY  - JOUR
AU  - Yeary, Karen H Kim
AU  - Clark, Nikia
AU  - Saad-Harfouche, Frances
AU  - Erwin, Deborah
AU  - Kuliszewski, Margaret Gates
AU  - Li, Qiang
AU  - McCann, Susan E
AU  - Yu, Han
AU  - Lincourt, Catherine
AU  - Zoellner, Jamie
AU  - Tang, Li
PY  - 2022
DA  - 2022/2/15
TI  - Cruciferous Vegetable Intervention to Reduce the Risk of Cancer Recurrence in Non–Muscle-Invasive Bladder Cancer Survivors: Development Using a Systematic Process
JO  - JMIR Cancer
SP  - e32291
VL  - 8
IS  - 1
KW  - non–muscle invasive bladder cancer survivors
KW  - dietary intervention
KW  - cruciferous vegetable
KW  - cancer survivorship
KW  - cancer recurrence
AB  - Background: Bladder cancer is one of the top 10 most common cancers in the United States. Most bladder cancers (70%-80%) are diagnosed at early stages as non–muscle-invasive bladder cancer (NMIBC), which can be removed surgically. However, 50% to 80% of NMIBC cases recur within 5 years, and 15% to 30% progress with poor survival. Current treatments are limited and expensive. A wealth of preclinical and epidemiological evidence suggests that dietary isothiocyanates in cruciferous vegetables (Cruciferae) could be a novel, noninvasive, and cost-effective strategy to control NMIBC recurrence and progression. Objective: The aim of this study is to develop a scalable dietary intervention that increases isothiocyanate exposure through Cruciferae intake in NMIBC survivors. Methods: We worked with a community advisory board (N=8) to identify relevant factors, evidence-based behavior change techniques, and behavioral theory constructs used to increase Cruciferae intake in NMIBC survivors; use the PEN-3 Model focused on incorporating cultural factors salient to the group’s shared experiences to review the intervention components (eg, the saliency of behavioral messages); administer the revised intervention to community partners for their feedback; and refine the intervention. Results: We developed a multicomponent intervention for NMIBC survivors consisting of a magazine, tracking book, live telephone call script, and interactive voice messages. Entitled POW-R Health: Power to Redefine Your Health, the intervention incorporated findings from our adaptation process to ensure saliency to NMIBC survivors. Conclusions: This is the first evidence-based, theoretically grounded dietary intervention developed to reduce bladder cancer recurrence in NMIBC survivors using a systematic process for community adaptation. This study provides a model for others who aim to develop behavioral, community-relevant interventions for cancer prevention and control with the overall goal of wide-scale implementation and dissemination. 
SN  - 2369-1999
UR  - https://cancer.jmir.org/2022/1/e32291
UR  - https://doi.org/10.2196/32291
UR  - http://www.ncbi.nlm.nih.gov/pubmed/35166681
DO  - 10.2196/32291
ID  - info:doi/10.2196/32291
ER  -