TY  - JOUR
AU  - Hoadley, Ariel
AU  - Fleisher, Linda
AU  - Kenny, Cassidy
AU  - Kelly, Patrick JA
AU  - Ma, Xinrui
AU  - Wu, Jingwei
AU  - Guerra, Carmen
AU  - Leader, Amy E
AU  - Alhajji, Mohammed
AU  - D’Avanzo, Paul
AU  - Landau, Zoe
AU  - Bass, Sarah Bauerle
PY  - 2024
DA  - 2024/9/30
TI  - Exploring Racial Disparities in Awareness and Perceptions of Oncology Clinical Trials: Cross-Sectional Analysis of Baseline Data From the mychoice Study
JO  - JMIR Cancer
SP  - e56048
VL  - 10
KW  - oncology clinical trial
KW  - cancer
KW  - decision-making
KW  - racial disparity
KW  - medical mistrust
AB  - Background: Black/African American adults are underrepresented in oncology clinical trials in the United States, despite efforts at narrowing this disparity. Objective: This study aims to explore differences in how Black/African American oncology patients perceive clinical trials to improve support for the clinical trial participation decision-making process. Methods: As part of a larger randomized controlled trial, a total of 244 adult oncology patients receiving active treatment or follow-up care completed a cross-sectional baseline survey on sociodemographic characteristics, clinical trial knowledge, health literacy, perceptions of cancer clinical trials, patient activation, patient advocacy, health care self-efficacy, decisional conflict, and clinical trial intentions. Self-reported race was dichotomized into Black/African American and non–Black/African American. As appropriate, 2-tailed t tests and chi-square tests of independence were used to examine differences between groups. Results: Black/African American participants had lower clinical trial knowledge (P=.006), lower health literacy (P<.001), and more medical mistrust (all P values <.05) than non–Black/African American participants. While intentions to participate in a clinical trial, if offered, did not vary between Black/African American and non–Black/African American participants, Black/African American participants indicated lower awareness of clinical trials, fewer benefits of clinical trials, and more uncertainty around clinical trial decision-making (all P values <.05). There were no differences for other variables. Conclusions: Despite no significant differences in intent to participate in a clinical trial if offered and high overall trust in individual health care providers among both groups, beliefs persist about barriers to and benefits of clinical trial participation among Black/African American patients. Findings highlight specific ways that education and resources about clinical trials could be tailored to better suit the informational and decision-making needs and preferences of Black/African American oncology patients. 
SN  - 2369-1999
UR  - https://cancer.jmir.org/2024/1/e56048
UR  - https://doi.org/10.2196/56048
DO  - 10.2196/56048
ID  - info:doi/10.2196/56048
ER  -