%0 Journal Article
%@ 2369-1999
%I JMIR Publications
%V 8
%N 1
%P e32291
%T Cruciferous Vegetable Intervention to Reduce the Risk of Cancer Recurrence in Non–Muscle-Invasive Bladder Cancer Survivors: Development Using a Systematic Process
%A Yeary,Karen H Kim
%A Clark,Nikia
%A Saad-Harfouche,Frances
%A Erwin,Deborah
%A Kuliszewski,Margaret Gates
%A Li,Qiang
%A McCann,Susan E
%A Yu,Han
%A Lincourt,Catherine
%A Zoellner,Jamie
%A Tang,Li
%+ Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, United States, 1 716 845 1300 ext 6231, karen.yeary@roswellpark.org
%K non–muscle invasive bladder cancer survivors
%K dietary intervention
%K cruciferous vegetable
%K cancer survivorship
%K cancer recurrence
%D 2022
%7 15.2.2022
%9 Original Paper
%J JMIR Cancer
%G English
%X Background: Bladder cancer is one of the top 10 most common cancers in the United States. Most bladder cancers (70%-80%) are diagnosed at early stages as non–muscle-invasive bladder cancer (NMIBC), which can be removed surgically. However, 50% to 80% of NMIBC cases recur within 5 years, and 15% to 30% progress with poor survival. Current treatments are limited and expensive. A wealth of preclinical and epidemiological evidence suggests that dietary isothiocyanates in cruciferous vegetables (Cruciferae) could be a novel, noninvasive, and cost-effective strategy to control NMIBC recurrence and progression. Objective: The aim of this study is to develop a scalable dietary intervention that increases isothiocyanate exposure through Cruciferae intake in NMIBC survivors. Methods: We worked with a community advisory board (N=8) to identify relevant factors, evidence-based behavior change techniques, and behavioral theory constructs used to increase Cruciferae intake in NMIBC survivors; use the PEN-3 Model focused on incorporating cultural factors salient to the group’s shared experiences to review the intervention components (eg, the saliency of behavioral messages); administer the revised intervention to community partners for their feedback; and refine the intervention. Results: We developed a multicomponent intervention for NMIBC survivors consisting of a magazine, tracking book, live telephone call script, and interactive voice messages. Entitled POW-R Health: Power to Redefine Your Health, the intervention incorporated findings from our adaptation process to ensure saliency to NMIBC survivors. Conclusions: This is the first evidence-based, theoretically grounded dietary intervention developed to reduce bladder cancer recurrence in NMIBC survivors using a systematic process for community adaptation. This study provides a model for others who aim to develop behavioral, community-relevant interventions for cancer prevention and control with the overall goal of wide-scale implementation and dissemination. 
%M 35166681
%R 10.2196/32291
%U https://cancer.jmir.org/2022/1/e32291
%U https://doi.org/10.2196/32291
%U http://www.ncbi.nlm.nih.gov/pubmed/35166681