%0 Journal Article
%@ 2369-1999
%I JMIR Publications
%V 10
%N 
%P e56048
%T Exploring Racial Disparities in Awareness and Perceptions of Oncology Clinical Trials: Cross-Sectional Analysis of Baseline Data From the mychoice Study
%A Hoadley,Ariel
%A Fleisher,Linda
%A Kenny,Cassidy
%A Kelly,Patrick JA
%A Ma,Xinrui
%A Wu,Jingwei
%A Guerra,Carmen
%A Leader,Amy E
%A Alhajji,Mohammed
%A D’Avanzo,Paul
%A Landau,Zoe
%A Bass,Sarah Bauerle
%+ Department of Social and Behavioral Sciences, Temple University College of Public Health, 9th Fl, 1301 Cecil B Moore Ave, Philadelphia, PA, 19122, United States, 1 215 204 0377, ariel.hoadley@temple.edu
%K oncology clinical trial
%K cancer
%K decision-making
%K racial disparity
%K medical mistrust
%D 2024
%7 30.9.2024
%9 Original Paper
%J JMIR Cancer
%G English
%X Background: Black/African American adults are underrepresented in oncology clinical trials in the United States, despite efforts at narrowing this disparity. Objective: This study aims to explore differences in how Black/African American oncology patients perceive clinical trials to improve support for the clinical trial participation decision-making process. Methods: As part of a larger randomized controlled trial, a total of 244 adult oncology patients receiving active treatment or follow-up care completed a cross-sectional baseline survey on sociodemographic characteristics, clinical trial knowledge, health literacy, perceptions of cancer clinical trials, patient activation, patient advocacy, health care self-efficacy, decisional conflict, and clinical trial intentions. Self-reported race was dichotomized into Black/African American and non–Black/African American. As appropriate, 2-tailed t tests and chi-square tests of independence were used to examine differences between groups. Results: Black/African American participants had lower clinical trial knowledge (P=.006), lower health literacy (P<.001), and more medical mistrust (all P values <.05) than non–Black/African American participants. While intentions to participate in a clinical trial, if offered, did not vary between Black/African American and non–Black/African American participants, Black/African American participants indicated lower awareness of clinical trials, fewer benefits of clinical trials, and more uncertainty around clinical trial decision-making (all P values <.05). There were no differences for other variables. Conclusions: Despite no significant differences in intent to participate in a clinical trial if offered and high overall trust in individual health care providers among both groups, beliefs persist about barriers to and benefits of clinical trial participation among Black/African American patients. Findings highlight specific ways that education and resources about clinical trials could be tailored to better suit the informational and decision-making needs and preferences of Black/African American oncology patients. 
%R 10.2196/56048
%U https://cancer.jmir.org/2024/1/e56048
%U https://doi.org/10.2196/56048